Pharmacokinetic and pharmacodynamic characteristics of a new S-amlodipine formulation in healthy Korean male subjects: A randomized, open-label, two-period, comparative, crossover study

• Published in: Clinical therapeutics Vol. 28; no. 11; pp. 1837 - 1847
• Main Authors: Park, Ji-Young, Kim, Kyoung-Ah, Park, Pil-Whan, Lee, Ock-Je, Hyeon Ryu, Jong, Hyeog Lee, Geun, Choun Ha, Mun, Sun Kim, Jin, Woo Kang, Seoung, Ryul Lee, Kyung
• Format: Journal Article
• Language: English
• Published: Belle Mead, NJ EM Inc USA 01.11.2006; Excerpta Medica; Elsevier Limited
• Subjects: Adult; amlodipine; Amlodipine - adverse effects; Amlodipine - chemistry; Amlodipine - pharmacokinetics; Amlodipine - pharmacology; Angina Pectoris - drug therapy; Asian Continental Ancestry Group; Bioavailability; Bioequivalence; Biological and medical sciences; Blood Pressure - drug effects; Calcium Channel Blockers - adverse effects; Calcium Channel Blockers - chemistry; Calcium Channel Blockers - pharmacokinetics; Calcium Channel Blockers - pharmacology; chiral drug; chiral switching; Cross-Over Studies; enantiomer; Heart Rate - drug effects; Humans; Hypertension - drug therapy; Korea; Male; Medical sciences; Metabolism; Middle Aged; Pharmacodynamics; Pharmacokinetics; Pharmacology. Drug treatments; S-amlodipine; Stereoisomerism; Toxicology; Asia; Korea; United States > US; S-amlodipine; enantiomer; chiral switching; amlodipine; chiral drug; Antianginal agent; Human; Drug; Pharmacokinetic pharmacodynamic relationship; Healthy subject; Calcium antagonist; Crossover study; Switching; Randomization; Enantiomer; Formulation; Amlodipine; Antihypertensive agent; Dihydropyridine derivatives; Comparative study

Amlodipine, a dihydropyridine calcium channel antagonist, is prescribed for the management of angina and hypertension. It is used therapeutically as a racemic mixture, composed of S- and R-enantiomers, but its calcium channel-blocking effect is confined to S-amlodipine; R-amlodipine has 1000-fold le...