Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss

• Published in: Molecular human reproduction Vol. 17; no. 7; pp. 447 - 452
• Main Authors: Miyamura, Hironori, Nishizawa, Haruki, Ota, Sayuri, Suzuki, Machiko, Inagaki, Ayaka, Egusa, Hiromi, Nishiyama, Sachie, Kato, Takema, Pryor-Koishi, Kanako, Nakanishi, Isao, Fujita, Tomio, Imayoshi, Yuzo, Markoff, Arseni, Yanagihara, Itaru, Udagawa, Yasuhiro, Kurahashi, Hiroki
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.07.2011
• Subjects: 5' Untranslated Regions; Abortion; Abortion, Habitual - epidemiology; Abortion, Habitual - genetics; Adult; Annexin A5 - genetics; Annexins; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Data processing; Embryology: invertebrates and vertebrates. Teratology; Etiology; Female; Fetuses; Fundamental and applied biological sciences. Psychology; Gene polymorphism; Genetic Predisposition to Disease - genetics; genomics; Haplotypes; Humans; Polymorphism, Genetic - genetics; Population genetics; Pregnancy; Pregnancy Complications - genetics; Promoter Regions, Genetic - genetics; Promoters; Risk factors; Single-nucleotide polymorphism; Asia; Japan; annexin A5; promoter; haplotype; SNP; recurrent pregnancy loss; Human; Relapse; Pregnancy disorders; Transcription promoter; Abortion; Japanese; Female; Haplotype; Annexin; Polymorphism

Recent findings have raised the possibility that polymorphisms within the annexin A5 gene (ANXA5) promoter contribute to the etiology of recurrent pregnancy loss (RPL). In our present study, 243 Japanese women who had suffered more than three fetal losses and a group of 119 fertile controls were gen...