Smoking history and serum cotinine and thiocyanate concentrations as determinants of rheumatoid factor in non-rheumatoid subjects

• Published in: Rheumatology (Oxford, England) Vol. 43; no. 11; pp. 1424 - 1428
• Main Authors: Korpilähde, T., Heliövaara, M., Knekt, P., Marniemi, J., Aromaa, A., Aho, K.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.11.2004; Oxford Publishing Limited (England)
• Subjects: Adult; Aged; Arthritis, Rheumatoid - diagnosis; Biological and medical sciences; Biomarkers - blood; Cotinine; Cotinine - blood; Diseases of the osteoarticular system; False Positive Reactions; Female; Health Surveys; Humans; Male; Medical sciences; Middle Aged; Odds Ratio; Rheumatoid factor; Rheumatoid Factor - blood; Smoking; Smoking - blood; Thiocyanates - blood; Tobacco, tobacco smoking; Toxicology; Human; Rheumatoid factor; Concentration factor; CNS stimulant; Psychotropic; Rheumatology; Tobacco smoking; Antidepressant agent; Serum; Cotinine; Case history; Smoking

Objectives. Smoking is associated with false-positive rheumatoid factor (RF). We explored the dose–response relationship of this association, using smoking history and serum cotinine and thiocyanate concentrations as measures of tobacco exposure. Methods. A total of 6947 men and women aged 30 yr or...