Vitamin E succinate mediated apoptosis by juxtaposing endoplasmic reticulum and mitochondria

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 12; p. 130485
• Main Authors: Ray, Manobendro Nath, Kiyofuji, Michiko, Ozono, Mizune, Kogure, Kentaro
• Format: Journal Article
• Language: English
• Published: 01.12.2023
• Subjects: alpha-tocopherol; antagonists; antineoplastic agents; apoptosis; calcium; endoplasmic reticulum; esterification; fluorescence microscopy; inositols; mitochondria; protein content; succinic acid; transmission electron microscopy

Vitamin E succinate (VES) is an esterified form of natural α-tocopherol, has turned out to be novel anticancer agent. However, its anticancer mechanisms have not been illustrated. Previously, we reported VES mediated Ca2+ release from the endoplasmic reticulum (ER) causes mitochondrial Ca2+ overload...