Development of Therapeutic Combinations Targeting Major Cancer Signaling Pathways

• Published in: Journal of clinical oncology Vol. 31; no. 12; pp. 1592 - 1605
• Main Authors: Yap, Timothy A., Omlin, Aurelius, de Bono, Johann S.
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Society of Clinical Oncology 20.04.2013
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Biomarkers, Tumor - metabolism; Drug Design; Humans; Medical sciences; Molecular Targeted Therapy; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Neoplasms - drug therapy; Neoplasms - metabolism; Signal Transduction - drug effects; Tumors; Cancerology; Treatment; Malignant tumor; Signaling pathway; Targeted therapy; Cancer

Signaling networks play key homeostatic processes in living organisms but are commonly hijacked in oncogenesis. Prominent examples include genetically altered receptor tyrosine kinases and dysregulated intracellular signaling molecules. The discovery and development of targeted therapies against suc...