Therapeutic Potential of Natural Compounds to Modulate WNT/β-Catenin Signaling in Cancer: Current State of Art and Challenges

• Published in: International journal of molecular sciences Vol. 25; no. 23; p. 12804
• Main Authors: Gajos-Michniewicz, Anna, Czyz, Malgorzata
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2024
• Subjects: Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; beta Catenin - metabolism; Biological Products - pharmacology; Biological Products - therapeutic use; Cancer therapies; Colorectal cancer; Drug resistance; Genes; Glycoproteins; Growth factors; Health aspects; Humans; Immunotherapy; Kinases; Ligands; Liver cancer; Medical research; Medicine, Experimental; Melanoma; Metastasis; Molecular Targeted Therapy - methods; Mutation; Neoplasms - drug therapy; Neoplasms - metabolism; Ovarian cancer; Plasma; Proteins; Wnt Signaling Pathway - drug effects; natural compounds; WNT/β-catenin signaling; cancer; clinical trials; WNT modulators

Targeted therapies and immunotherapies have improved the clinical outcome of cancer patients; however, the efficacy of treatment remains frequently limited due to low predictability of response and development of drug resistance. Therefore, novel therapeutic strategies for various cancer types are n...