Drug interaction assessment following concomitant administration of posaconazole and phenytoin in healthy men

• Published in: Current medical research and opinion Vol. 23; no. 6; pp. 1415 - 1422
• Main Authors: Krishna, Gopal, Sansone-Parsons, Angela, Kantesaria, Bhavna
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.06.2007; Taylor & Francis; Informa Healthcare
• Subjects: Administration, Oral; Adolescent; Adult; Anticonvulsants - administration & dosage; Anticonvulsants - adverse effects; Anticonvulsants - blood; Anticonvulsants - pharmacokinetics; Antifungal Agents - administration & dosage; Antifungal Agents - adverse effects; Antifungal Agents - blood; Antifungal Agents - pharmacokinetics; Drug Administration Schedule; Drug interaction; Drug Interactions; Humans; Male; Middle Aged; Pharmacokinetics; Phenytoin; Phenytoin - administration & dosage; Phenytoin - adverse effects; Phenytoin - blood; Phenytoin - pharmacokinetics; Polypharmacy; Posaconazole; Safety; Time Factors; Triazoles - administration & dosage; Triazoles - adverse effects; Triazoles - blood; Triazoles - pharmacokinetics

ABSTRACT Objective: Posaconazole is an extended-spectrum triazole antifungal agent for the treatment and prophylaxis of invasive fungal infections. This randomized, open-label, parallel-group, multiple-dose study was conducted in healthy adult volunteers to assess the potential for a drug interactio...