Acquired type 2A von Willebrand syndrome caused by aortic valve disease corrects during valve surgery

• Published in: British journal of anaesthesia : BJA Vol. 106; no. 4; pp. 494 - 500
• Main Authors: Solomon, C., Budde, U., Schneppenheim, S., Czaja, E., Hagl, C., Schoechl, H., von Depka, M., Rahe-Meyer, N.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.04.2011; Oxford University Press
• Subjects: Adult; Aged; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Aortic Valve - surgery; Biological and medical sciences; Blood Coagulation Tests - methods; Blood Transfusion; coagulation; Coronary Artery Bypass; Female; Heart Valve Diseases - blood; Heart Valve Diseases - complications; Heart Valve Diseases - surgery; Humans; Male; Medical sciences; Middle Aged; Postoperative Care - methods; Prospective Studies; surgery, cardiovascular; von Willebrand Disease, Type 2 - blood; von Willebrand Disease, Type 2 - etiology; von Willebrand Disease, Type 2 - therapy; von Willebrand Factor - immunology; von Willebrand Factor - metabolism; coagulation; surgery, cardiovascular; Cardiac valvular disease; Surgery; Cardiovascular disease; Anesthesia; Aortic valve disease; cardiovascular

Aortic valve (AV) defects can destroy high molecular weight multimers (HMWM) of von Willebrand factor (VWF), leading to acquired von Willebrand syndrome (aVWS) type IIA. This syndrome is considered a cause for increased perioperative bleeding in AV surgery. If diagnosed before operation, administrat...