Evaluation of chromosome aberrations, sister chromatid exchange and micronuclei in patients with type-1 diabetes mellitus

• Published in: Mutation research Vol. 676; no. 1; pp. 1 - 4
• Main Authors: Cinkilic, Nilüfer, Kiyici, Sinem, Celikler, Serap, Vatan, Ozgur, Oz Gul, Ozen, Tuncel, Ercan, Bilaloglu, Rahmi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 31.05.2009; Elsevier
• Subjects: Adult; Animals; Biological and medical sciences; Blood Glucose - metabolism; Chromosome Aberrations; Chromosomes, Human, Pair 1 - ultrastructure; Chromosomes, Human, Pair 11 - ultrastructure; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - metabolism; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Glycated Hemoglobin A - metabolism; Humans; Hydrogen Peroxide - toxicity; Male; Medical sciences; Micronucleus formation; Micronucleus Tests; Occupational Exposure - adverse effects; Oxidative Stress - genetics; Sister Chromatid Exchange; Toxicology; Type-1 diabetes; Sister chromatid exchange; Micronucleus formation; Chromosome aberrations; Type-1 diabetes; Endocrinopathy; Chromosomal aberration; Human; Immunopathology; Mutagenicity testing; Autoimmune disease; Toxicology; Type 1 diabetes; Micronucleus; Genetics

Oxidative stress-induced DNA damage seems to play a role in the pathogenesis of type-1 diabetes mellitus and its complications. Several in vitro assays have been used to measure the DNA damage produced by oxidative stress. In the present study, we aimed to investigate the frequency of sister chromat...