Collective effects of common SNPs and risk prediction in lung cancer

• Published in: Heredity Vol. 121; no. 6; pp. 537 - 547
• Main Authors: Lei, Xiaoyun, Yuan, Dejian, Zhu, Zuobin, Huang, Shi
• Format: Journal Article
• Language: English
• Published: England Springer Nature B.V 01.12.2018; Springer International Publishing
• Subjects: Alleles; Cancer; Case-Control Studies; Environmental factors; Finland; Genetic Predisposition to Disease; Genomes; Health risk assessment; Humans; Linkage disequilibrium; Lung cancer; Lung Neoplasms - genetics; Polymorphism, Single Nucleotide; Predictions; Principal Component Analysis; Single-nucleotide polymorphism; Smoking; United States; United States; Finland; United States > US

Lung cancer is the leading cause of cancer deaths in both men and women in the US. While most sporadic lung cancer cases are related to environmental factors such as smoking, genetic susceptibility may also play an important role and a number of lung cancer associated single-nucleotide polymorphisms...