Current Landscape in Clinical Pretargeted Radioimmunoimaging and Therapy

• Published in: Journal of Nuclear Medicine Vol. 62; no. 9; pp. 1200 - 1206
• Main Authors: Jallinoja, Vilma I J, Houghton, Jacob L
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.09.2021
• Subjects: Animals; Antibodies; Biotin; Bispecific antibodies; Focus on Molecular Imaging; Humans; Neoplasms - diagnostic imaging; Neoplasms - radiotherapy; Neoplasms - therapy; Nuclear medicine; Platforms; Radioimmunodetection; Radioimmunotherapy - methods; Streptavidin; radiopharmaceuticals; pretargeting; radioimmunotherapy; PET imaging; radionuclide therapy; radioimmunoimaging; molecular imaging; PET

The principle of pretargeted radioimmunoimaging and therapy has been investigated over the past 30 y in preclinical and clinical settings with the aim of reducing the radiation burden of healthy tissue for antibody-based nuclear medicine techniques. In the past few decades, 4 pretargeting methodolog...