Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma

• Published in: Journal of Nuclear Medicine Vol. 64; no. 1; pp. 137 - 144
• Main Authors: Shin, Jaehoon, Parker, Matthew F L, Zhu, Iowis, Alanizi, Aryn, Rodriguez, Carlos I, Liu, Raymond, Watchmaker, Payal B, Kalita, Mausam, Blecha, Joseph, Luu, Justin, Wright, Brian, Lapi, Suzanne E, Flavell, Robert R, Okada, Hideho, Tlsty, Thea D, Roybal, Kole T, Wilson, David M
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.01.2023
• Subjects: Animal models; Animals; Antigens; Biomarkers; Brain cancer; Breast cancer; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - genetics; Cell Line, Tumor; Chimeric antigen receptors; Epidermal growth factor; ErbB-2 protein; Female; Fluorescence; Fluorine isotopes; Gene expression; Genes, Reporter; Glioblastoma; Green fluorescent protein; Growth factors; Humans; In vivo methods and tests; Lymphocytes; Lymphocytes T; Positron emission; Positron-Emission Tomography - methods; Proteolysis; Receptors; Reporter gene; T-Lymphocytes; Tumor markers; Tumors; Xenografts; Xenotransplantation; reporter; cancer antigens; CAR T; SNIPR; PET

For the past several decades, chimeric antigen receptor T-cell therapies have shown promise in the treatment of cancers. These treatments would greatly benefit from companion imaging biomarkers to follow the trafficking of T cells in vivo. Using synthetic biology, we engineered T cells with a chimer...