Deletion of Dicer blocks osteogenic differentiation via the inhibition of Wnt signalling

• Published in: Molecular medicine reports Vol. 19; no. 4; pp. 2897 - 2905
• Main Authors: Wu, Hong‑Yan, Bi, Rui, Sun, Ting, Xie, Fei
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.04.2019; Spandidos Publications UK Ltd
• Subjects: Alkaline phosphatase; Bone growth; Bone marrow; Bone mass; Cell differentiation; Cellular signal transduction; Clonal deletion; Epigenetic inheritance; Epigenetics; Fetuses; Gene expression; Gene regulation; Genes; Glycerol; Homeostasis; Lymphocytes T; MicroRNA; miRNA; Molecular modelling; Nucleases; Osteoblastogenesis; Osteoblasts; Osteogenesis; Phosphatases; Proteins; RNA; Roles; Signal transduction; Stromal cells; Studies; T cells; Transcription factors; Wnt protein; Atlanta Georgia; United States > US

Micro (mi)RNAs are small, non‑coding RNAs and have been reported to have important roles in the epigenetic control of bone development. miRNAs markedly regulate osteoblast differentiation through stages of maturation as well as the activities of osteogenic signaling pathways. Dicer is an important e...