Toxicity Evaluation of Nanostructured Silica Orally Administered to Rats: Influence on Immune System Function

• Published in: Nanomaterials (Basel, Switzerland) Vol. 10; no. 11; p. 2126
• Main Authors: Gmoshinski, Ivan V., Shipelin, Vladimir A., Shumakova, Antonina A., Trushina, Eleonora N., Mustafina, Oksana K., Safenkova, Irina V., Khotimchenko, Sergey A., Nikityuk, Dmitry B., Tutelyan, Viktor A.
• Format: Journal Article
• Language: English
• Published: MDPI 26.10.2020; MDPI AG
• Subjects: cellular immunity; leucocytes; nanoparticles; rats; silica; subacute toxicity

The experimental data on the oral toxicity of nanostructured amorphous silica (SiO2), widely used in food supplements, pharmaceuticals, and cosmetics, in terms of its in vivo effect on the immune system, are contradictory. Therefore, this study aimed to assess the rat’s immune function after SiO2 or...