Stereological analysis of forebrain regions in kainate-treated epileptic rats

• Published in: Brain research Vol. 1057; no. 1; pp. 141 - 152
• Main Authors: Chen, Shaoyun, Buckmaster, Paul S.
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 28.09.2005; Amsterdam Elsevier; New York, NY
• Subjects: Amygdala; Analysis of Variance; Animals; Biological and medical sciences; Brain Mapping; Cavalieri method; Cell Count - methods; Epilepsy - chemically induced; Epilepsy - physiopathology; Fundamental and applied biological sciences. Psychology; Glutamate Decarboxylase - genetics; Glutamate Decarboxylase - metabolism; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Imaging, Three-Dimensional - methods; In Situ Hybridization - methods; Isoenzymes - genetics; Isoenzymes - metabolism; Kainic Acid; Male; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Neurons - drug effects; Neurons - pathology; Olfactory cortex; Olfactory system and olfaction. Gustatory system and gustation; Piriform cortex; Prosencephalon - drug effects; Prosencephalon - pathology; Prosencephalon - physiopathology; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Temporal lobe epilepsy; Vertebrates: nervous system and sense organs; Cavalieri method; Olfactory cortex; Disorders of the nervous system; Temporal lobe epilepsy; Amygdala; Piriform cortex; Nervous system diseases; Rat; Rodentia; Central nervous system; Complex partial epilepsy; Basal ganglion; Cerebral disorder; Prosencephalon; Vertebrata; Mammalia; Olfactory pathway; Treatment; Animal; Central nervous system disease; Stereology; Kainic acid

Patients and models of temporal lobe epilepsy display neuron loss in the hippocampal formation, but neuropathological changes also occur in other forebrain regions. We sought to evaluate the specificity and extent of volume loss of the major forebrain regions in epileptic rats months after kainate-i...