Pleomorphic Adenoma With Prominent Clear Cell Myoepithelioma Component of the Lacrimal Gland

• Published in: Ophthalmic plastic and reconstructive surgery Vol. 32; no. 1; p. e18
• Main Authors: Adekunle, Adewumi N, Mendoza, Pia R, Wojno, Ted H, Grossniklaus, Hans E
• Format: Journal Article
• Language: English
• Published: United States 01.01.2016
• Subjects: Adenoma, Pleomorphic - metabolism; Adenoma, Pleomorphic - pathology; Adenoma, Pleomorphic - surgery; Aged, 80 and over; Biomarkers, Tumor - metabolism; Eye Neoplasms - metabolism; Eye Neoplasms - pathology; Eye Neoplasms - surgery; Female; Humans; Lacrimal Apparatus Diseases - metabolism; Lacrimal Apparatus Diseases - pathology; Lacrimal Apparatus Diseases - surgery; Myoepithelioma - metabolism; Myoepithelioma - pathology; Myoepithelioma - surgery; Neoplasm Proteins - metabolism
• DOI: 10.1097/IOP.0000000000000374

A case of a pleomorphic adenoma of the lacrimal gland with a prominent clear cell myoepitheliomatous component was reported. An 81-year-old Caucasian woman experienced a 2-month history of right supraorbital swelling and proptosis. Excisional biopsy revealed a multicomponent lesion including a stromal component featuring glandular structures made of small epithelioid and spindle cells and a trabecular component with small islands of vacuolated cells, displaced nuclei, and clear cytoplasm. Immunohistochemical analysis revealed strong cytokeratin AE1/3 reactivity and focal smooth muscle actin positivity. The pathologic findings including immunohistochemistry results were consistent with a pleomorphic adenoma with prominent clear cell myoepithelioma component.