Using marginal structural models to analyze randomized clinical trials with non-adherence and lost to follow up

• Published in: Annals of epidemiology Vol. 63; pp. 22 - 28
• Main Authors: Lancet, Elizabeth A., Borrell, Luisa N., Holbrook, Janet, Morabia, Alfredo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2021
• Subjects: Causalinference; Clinical trials; Humans; Intention to treat; Intention to Treat Analysis; Inverse probability weighting; Lost to Follow-Up; Marginal structural models; Models, Structural; Patient Compliance; Randomized Controlled Trials as Topic; Clinical trials; Inverse probability weighting; Causalinference; Intention to treat; Marginal structural models

•Unlike the Intention-to-Treat approach, Marginal Structural Models can account for the effects of time-varying treatments in the presence of censoring and time-dependent confounding influenced by prior treatment.•A randomized clinical trial on asthma treatment was used as working model to determine...