Interferon gamma-inducible protein 16 in primary Sjögren’s syndrome: a novel player in disease pathogenesis?

• Published in: Arthritis research & therapy Vol. 17; no. 1; p. 208
• Main Authors: Alunno, Alessia, Caneparo, Valeria, Carubbi, Francesco, Bistoni, Onelia, Caterbi, Sara, Bartoloni, Elena, Giacomelli, Roberto, Gariglio, Marisa, Landolfo, Santo, Gerli, Roberto
• Format: Journal Article
• Language: English
• Published: England BioMed Central 14.08.2015
• Subjects: Arthritis; Biomarkers - blood; Female; Humans; Male; Middle Aged; Nuclear Proteins - blood; Phosphoproteins - blood; Sjogren's Syndrome - blood; Sjogren's Syndrome - diagnosis; T-Lymphocytes - metabolism

There is evidence that interferon is involved in the pathogenesis of primary Sjögren's syndrome (pSS). The interferon-inducible IFI16 protein, normally expressed in cell nuclei, may be overexpressed, mislocalized in the cytoplasm and secreted in the extracellular milieu in several autoimmune di...