Therapeutic importance of hydrogen sulfide in cognitive impairment diseases

• Published in: Brain research Vol. 1856; p. 149547
• Main Authors: Wei, Hai-Jun, Tan, Hui-Ying, Cao, Jian-Ping, He, Juan, Zhang, Qing-Li, Jiang, Li, Zhou, Gui-Juan, Xiao, Fan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2025
• Subjects: Animals; Antioxidant; Brain - drug effects; Brain - metabolism; Cognitive Dysfunction - drug therapy; Cognitive Dysfunction - metabolism; Cognitive impairment; Cystathionine beta-Synthase - metabolism; Endoplasmic reticulum stress; Humans; Hydrogen sulfide; Hydrogen Sulfide - metabolism; Hydrogen Sulfide - pharmacology; Hydrogen Sulfide - therapeutic use; Inflammation; Neurology; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; NMDA receptors; Hydrogen sulfide; Inflammation; Antioxidant; NMDA receptors; Cognitive impairment; Endoplasmic reticulum stress

[Display omitted] •H2S, synthesized by brain enzymes, functions as a neuromodulator with antioxidant and neuroprotective properties.•Lower H2S levels in cognitive disorders highlight its key role in learning and memory regulation.•Preclinical studies show H2S improves cognition in neurodegenerative,...