Theoretical and computational studies of dendrimers as delivery vectors

• Published in: Chemical Society reviews Vol. 42; no. 2; pp. 705 - 727
• Main Authors: Tian, Wen-de, Ma, Yu-qiang
• Format: Journal Article
• Language: English
• Published: England 01.01.2013
• Subjects: Animals; Biomolecules; Computation; Computer Simulation; Dendrimers; Dendrimers - chemistry; Dendrimers - metabolism; Drug Carriers - chemistry; Drug Carriers - metabolism; Genes; Humans; Lipid Bilayers - metabolism; Mathematical analysis; Models, Molecular; Nanostructure; Nucleic Acids - administration & dosage; Nucleic Acids - metabolism; Pharmaceutical Preparations - administration & dosage; Pharmaceutical Preparations - metabolism; Proteins - metabolism; Vectors (mathematics)

It is a great challenge for nanomedicine to develop novel dendrimers with maximum therapeutic potential and minimum side-effects for drug and gene delivery. As delivery vectors, dendrimers must overcome lots of barriers before delivering the bio-agents to the target in the cell. Extensive experiment...