Alginate-chitosan Hydrogel Patch with Beta-glucan Nanoemulsion for Antibacterial Applications

Natural polymer materials have high biocompatibility and are not toxic because they can decompose into metabolites in the body; thus, they are widely used as medical polymer materials as well as porous support materials. As a biopolymer, alginate has a negative charge; in contrast, chitosan has a po...

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Published inBiotechnology and bioprocess engineering Vol. 26; no. 1; pp. 71 - 77
Main Authors Choi, Yonghyun, Jang, Jaehee, Koo, Hyung-Jun, Tanaka, Masayoshi, Lee, Keun-Heon, Choi, Jonghoon
Format Journal Article
LanguageEnglish
Published Seoul The Korean Society for Applied Biological Chemistry 01.02.2021
Springer Nature B.V
한국생물공학회
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ISSN1226-8372
1976-3816
DOI10.1007/s12257-020-0177-4

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Abstract Natural polymer materials have high biocompatibility and are not toxic because they can decompose into metabolites in the body; thus, they are widely used as medical polymer materials as well as porous support materials. As a biopolymer, alginate has a negative charge; in contrast, chitosan has a positive charge. Therefore, when the two substances are mixed, they form a relatively stable structure by ionic bonding. Beta-glucan is known to contribute to material stability and have high skin penetration, skin moisturizing and soothing effects, and burn and wound healing effects. In this study, antimicrobial activity was assessed by preparing alginate-chitosan hydrogel patches containing beta-glucan nanoemulsions. This could contribute to the development of wound dressings with antibacterial properties.
AbstractList Natural polymer materials have high biocompatibility and are not toxic because they can decompose into metabolites in the body; thus, they are widely used as medical polymer materials as well as porous support materials. As a biopolymer, alginate has a negative charge; in contrast, chitosan has a positive charge. Therefore, when the two substances are mixed, they form a relatively stable structure by ionic bonding. Beta-glucan is known to contribute to material stability and have high skin penetration, skin moisturizing and soothing effects, and burn and wound healing effects. In this study, antimicrobial activity was assessed by preparing alginate-chitosan hydrogel patches containing beta-glucan nanoemulsions. This could contribute to the development of wound dressings with antibacterial properties.
Natural polymer materials have high biocompatibility and are not toxic because they can decompose into metabolites in the body; thus, they are widely used as medical polymer materials as well as porous support materials. As a biopolymer, alginate has a negative charge; in contrast, chitosan has a positive charge. Therefore, when the two substances are mixed, they form a relatively stable structure by ionic bonding. Beta-glucan is known to contribute to material stability and have high skin penetration, skin moisturizing and soothing effects, and burn and wound healing effects. In this study, antimicrobial activity was assessed by preparing alginate-chitosan hydrogel patches containing beta-glucan nanoemulsions. This could contribute to the development of wound dressings with antibacterial properties. KCI Citation Count: 0
Author Tanaka, Masayoshi
Choi, Yonghyun
Choi, Jonghoon
Lee, Keun-Heon
Jang, Jaehee
Koo, Hyung-Jun
Author_xml – sequence: 1
  givenname: Yonghyun
  surname: Choi
  fullname: Choi, Yonghyun
  organization: School of Integrative Engineering, Chung-Ang University
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  givenname: Jaehee
  surname: Jang
  fullname: Jang, Jaehee
  organization: School of Integrative Engineering, Chung-Ang University
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  givenname: Hyung-Jun
  surname: Koo
  fullname: Koo, Hyung-Jun
  organization: Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology
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  givenname: Masayoshi
  surname: Tanaka
  fullname: Tanaka, Masayoshi
  organization: Department of Chemical Science and Engineering, Tokyo Institute of Technology
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  givenname: Keun-Heon
  surname: Lee
  fullname: Lee, Keun-Heon
  organization: Humas
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  givenname: Jonghoon
  surname: Choi
  fullname: Choi, Jonghoon
  email: nanomed@cau.ac.kr
  organization: School of Integrative Engineering, Chung-Ang University
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Snippet Natural polymer materials have high biocompatibility and are not toxic because they can decompose into metabolites in the body; thus, they are widely used as...
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SubjectTerms Alginates
Alginic acid
Antimicrobial activity
beta-glucans
Biocompatibility
Biopolymers
bioprocessing
Biotechnology
Chemistry
Chitosan
Emulsions
Glucan
Hydrogels
Industrial and Production Engineering
Medical materials
Metabolites
Nanoemulsions
Natural polymers
Polymers
Porous materials
Research Paper
toxicity
Wound healing
β-Glucan
생물공학
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Title Alginate-chitosan Hydrogel Patch with Beta-glucan Nanoemulsion for Antibacterial Applications
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