Novel liquid fermentation medium of Cordyceps militaris and optimization of hydrothermal reflux extraction of cordycepin

In this study, we developed a novel liquid fermentation medium of Cordyceps militaris using pupa powder and wheat bran as nitrogen resources instead of the traditionally used peptone. This process not only reduced the cost by approximately 50%, but increased production by over 30%. Then, we explored...

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Published inJournal of asian natural products research Vol. 22; no. 2; pp. 167 - 178
Main Authors Luo, Qing-Ying, Cao, Hong-Fu, Liu, Shu-Kun, Wu, Min, Li, Shan-Shan, Zhang, Zhi-Qing, Chen, An-Jun, Shen, Guang-Hui, Wu, He-Jun, Li, Mei-Liang, Liu, Xing-Yan, Jiang, Yong, Bi, Jun-Fei, He, Zheng-You
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.02.2020
Taylor & Francis Ltd
Subjects
adsorption
Cordycepin
Cordyceps
Cordyceps militaris
cost reduction
Deoxyadenosines
Fermentation
hydrothermal exaction
Industrial production
liquid fermentation
liquid state fermentation
Molecular Structure
nitrogen
Optimization
Peptones
porous media
pupae
Resins
Wheat
Wheat bran
cost reduction
hydrothermal exaction
liquid fermentation
Cordyceps militaris
cordycepin
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Abstract In this study, we developed a novel liquid fermentation medium of Cordyceps militaris using pupa powder and wheat bran as nitrogen resources instead of the traditionally used peptone. This process not only reduced the cost by approximately 50%, but increased production by over 30%. Then, we explored a method to extract and purify cordycepin by combining hydrothermal reflux extraction with macroporous resin adsorption, which is inexpensive and suitable for the industrial production. The optimum conditions for hydrothermal reflux were extracting three times at 95 °C with 1:10 sample-to-water ratio, and the cordycepin purity with macroporous resin HPD-100 reached 95.23%.
AbstractList In this study, we developed a novel liquid fermentation medium of Cordyceps militaris using pupa powder and wheat bran as nitrogen resources instead of the traditionally used peptone. This process not only reduced the cost by approximately 50%, but increased production by over 30%. Then, we explored a method to extract and purify cordycepin by combining hydrothermal reflux extraction with macroporous resin adsorption, which is inexpensive and suitable for the industrial production. The optimum conditions for hydrothermal reflux were extracting three times at 95 °C with 1:10 sample-to-water ratio, and the cordycepin purity with macroporous resin HPD-100 reached 95.23%.
In this study, we developed a novel liquid fermentation medium of Cordyceps militaris using pupa powder and wheat bran as nitrogen resources instead of the traditionally used peptone. This process not only reduced the cost by approximately 50%, but increased production by over 30%. Then, we explored a method to extract and purify cordycepin by combining hydrothermal reflux extraction with macroporous resin adsorption, which is inexpensive and suitable for the industrial production. The optimum conditions for hydrothermal reflux were extracting three times at 95 °C with 1:10 sample-to-water ratio, and the cordycepin purity with macroporous resin HPD-100 reached 95.23%.[Formula: see text].In this study, we developed a novel liquid fermentation medium of Cordyceps militaris using pupa powder and wheat bran as nitrogen resources instead of the traditionally used peptone. This process not only reduced the cost by approximately 50%, but increased production by over 30%. Then, we explored a method to extract and purify cordycepin by combining hydrothermal reflux extraction with macroporous resin adsorption, which is inexpensive and suitable for the industrial production. The optimum conditions for hydrothermal reflux were extracting three times at 95 °C with 1:10 sample-to-water ratio, and the cordycepin purity with macroporous resin HPD-100 reached 95.23%.[Formula: see text].
In this study, we developed a novel liquid fermentation medium of using pupa powder and wheat bran as nitrogen resources instead of the traditionally used peptone. This process not only reduced the cost by approximately 50%, but increased production by over 30%. Then, we explored a method to extract and purify cordycepin by combining hydrothermal reflux extraction with macroporous resin adsorption, which is inexpensive and suitable for the industrial production. The optimum conditions for hydrothermal reflux were extracting three times at 95 °C with 1:10 sample-to-water ratio, and the cordycepin purity with macroporous resin HPD-100 reached 95.23%.[Formula: see text].
Author Wu, Min
Li, Shan-Shan
Zhang, Zhi-Qing
Liu, Shu-Kun
Liu, Xing-Yan
Jiang, Yong
Bi, Jun-Fei
He, Zheng-You
Li, Mei-Liang
Chen, An-Jun
Cao, Hong-Fu
Wu, He-Jun
Shen, Guang-Hui
Luo, Qing-Ying
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  surname: Luo
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  givenname: Hong-Fu
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  organization: Department of Toxicology, Chengdu University of Traditional Chinese Medicine
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  organization: College of Food Science, Sichuan Agricultural University
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  organization: College of Food Science, Sichuan Agricultural University
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  organization: College of Food Science, Sichuan Agricultural University
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  fullname: Chen, An-Jun
  organization: College of Food Science, Sichuan Agricultural University
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  fullname: Shen, Guang-Hui
  organization: College of Food Science, Sichuan Agricultural University
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  fullname: Wu, He-Jun
  organization: College of Food Science, Sichuan Agricultural University
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  surname: Li
  fullname: Li, Mei-Liang
  organization: College of Food Science, Sichuan Agricultural University
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  organization: College of Food Science, Sichuan Agricultural University
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  organization: Department of Traditional Chinese Medicine, Sichuan Industrial Institute of Antibiotics
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  organization: College of Food Science, Sichuan Agricultural University
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  givenname: Zheng-You
  surname: He
  fullname: He, Zheng-You
  email: cherry12112009@163.com, 774324380@qq.com
  organization: Department of Traditional Chinese Medicine, Sichuan Industrial Institute of Antibiotics
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hydrothermal exaction
liquid fermentation
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cordycepin
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SubjectTerms adsorption
Cordycepin
Cordyceps
Cordyceps militaris
cost reduction
Deoxyadenosines
Fermentation
hydrothermal exaction
Industrial production
liquid fermentation
liquid state fermentation
Molecular Structure
nitrogen
Optimization
Peptones
porous media
pupae
Resins
Wheat
Wheat bran
Title Novel liquid fermentation medium of Cordyceps militaris and optimization of hydrothermal reflux extraction of cordycepin
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