Molecular mechanisms of cardiac protection by adaptation to chronic hypoxia

Effective protection of the heart against ischemia/reperfusion injury is one of the most important goals of experimental and clinical research in cardiology. Besides ischemic preconditioning as a powerful temporal protective phenomenon, adaptation to chronic hypoxia also increases cardiac tolerance...

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Bibliographic Details
Published inPhysiological research Vol. 53 Suppl 1; pp. S3 - S13
Main Authors Kolár, F, Ostádal, B
Format Journal Article
LanguageEnglish
Published Czech Republic 2004
Subjects
Adaptation, Physiological
Animals
Cell Hypoxia - physiology
Heart - physiology
Humans
Myocardial Ischemia - prevention & control
Nitric Oxide - physiology
Potassium Channels - physiology
Protein Kinases - physiology
Reactive Oxygen Species
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Summary:Effective protection of the heart against ischemia/reperfusion injury is one of the most important goals of experimental and clinical research in cardiology. Besides ischemic preconditioning as a powerful temporal protective phenomenon, adaptation to chronic hypoxia also increases cardiac tolerance to all major deleterious consequences of acute oxygen deprivation such as myocardial infarction, contractile dysfunction and ventricular arrhythmias. Although many factors have been proposed to play a potential role, the detailed mechanism of this long-term protection remains poorly understood. This review summarizes current limited evidence for the involvement of ATP-sensitive potassium channels, reactive oxygen species, nitric oxide and various protein kinases in cardioprotective effects of chronic hypoxia.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.930000.53.s3