Mouse polyQ database: a new online resource for research using mouse models of neurodegenerative diseases

The polyglutamine (polyQ) family of disorders comprises 9 genetic diseases, including several types of ataxia and Huntington disease. Approximately two decades of investigation and the creation of more than 130 mouse models of polyQ disorders have revealed many similarities between these diseases. T...

Full description

Saved in:
Bibliographic Details
Published inMolecular brain Vol. 8; no. 1; p. 69
Main Authors Szlachcic, Wojciech J, Switonski, Pawel M, Kurkowiak, Małgorzata, Wiatr, Kalina, Figiel, Maciej
Format Journal Article
LanguageEnglish
Published England BioMed Central 29.10.2015
Subjects
Online AccessGet full text

Cover

Loading…
Abstract The polyglutamine (polyQ) family of disorders comprises 9 genetic diseases, including several types of ataxia and Huntington disease. Approximately two decades of investigation and the creation of more than 130 mouse models of polyQ disorders have revealed many similarities between these diseases. The disorders share common mutation types, neurological characteristics and certain aspects of pathogenesis, including morphological and physiological neuronal alterations. All of the diseases still remain incurable. The large volume of information collected as a result of the investigation of polyQ models currently represents a great potential for searching, comparing and translating pathogenesis and therapeutic information between diseases. Therefore, we generated a public database comprising the polyQ mouse models, phenotypes and therapeutic interventions tested in vivo. The database is available at http://conyza.man.poznan.pl/ . The use of the database in the field of polyQ diseases may accelerate research on these and other neurodegenerative diseases and provide new perspectives for future investigation.
AbstractList The polyglutamine (polyQ) family of disorders comprises 9 genetic diseases, including several types of ataxia and Huntington disease. Approximately two decades of investigation and the creation of more than 130 mouse models of polyQ disorders have revealed many similarities between these diseases. The disorders share common mutation types, neurological characteristics and certain aspects of pathogenesis, including morphological and physiological neuronal alterations. All of the diseases still remain incurable. The large volume of information collected as a result of the investigation of polyQ models currently represents a great potential for searching, comparing and translating pathogenesis and therapeutic information between diseases. Therefore, we generated a public database comprising the polyQ mouse models, phenotypes and therapeutic interventions tested in vivo. The database is available at http://conyza.man.poznan.pl/ . The use of the database in the field of polyQ diseases may accelerate research on these and other neurodegenerative diseases and provide new perspectives for future investigation.
BACKGROUNDThe polyglutamine (polyQ) family of disorders comprises 9 genetic diseases, including several types of ataxia and Huntington disease. Approximately two decades of investigation and the creation of more than 130 mouse models of polyQ disorders have revealed many similarities between these diseases. The disorders share common mutation types, neurological characteristics and certain aspects of pathogenesis, including morphological and physiological neuronal alterations. All of the diseases still remain incurable.DESCRIPTIONThe large volume of information collected as a result of the investigation of polyQ models currently represents a great potential for searching, comparing and translating pathogenesis and therapeutic information between diseases. Therefore, we generated a public database comprising the polyQ mouse models, phenotypes and therapeutic interventions tested in vivo. The database is available at http://conyza.man.poznan.pl/ .CONCLUSIONThe use of the database in the field of polyQ diseases may accelerate research on these and other neurodegenerative diseases and provide new perspectives for future investigation.
Background The polyglutamine (polyQ) family of disorders comprises 9 genetic diseases, including several types of ataxia and Huntington disease. Approximately two decades of investigation and the creation of more than 130 mouse models of polyQ disorders have revealed many similarities between these diseases. The disorders share common mutation types, neurological characteristics and certain aspects of pathogenesis, including morphological and physiological neuronal alterations. All of the diseases still remain incurable. Description The large volume of information collected as a result of the investigation of polyQ models currently represents a great potential for searching, comparing and translating pathogenesis and therapeutic information between diseases. Therefore, we generated a public database comprising the polyQ mouse models, phenotypes and therapeutic interventions tested in vivo. The database is available at http://conyza.man.poznan.pl/. Conclusion The use of the database in the field of polyQ diseases may accelerate research on these and other neurodegenerative diseases and provide new perspectives for future investigation.
ArticleNumber 69
Author Figiel, Maciej
Switonski, Pawel M
Wiatr, Kalina
Szlachcic, Wojciech J
Kurkowiak, Małgorzata
Author_xml – sequence: 1
  givenname: Wojciech J
  surname: Szlachcic
  fullname: Szlachcic, Wojciech J
  email: wjsz@ibch.poznan.pl
  organization: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznań, Poland. wjsz@ibch.poznan.pl
– sequence: 2
  givenname: Pawel M
  surname: Switonski
  fullname: Switonski, Pawel M
  email: pswiton@ibch.poznan.pl
  organization: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznań, Poland. pswiton@ibch.poznan.pl
– sequence: 3
  givenname: Małgorzata
  surname: Kurkowiak
  fullname: Kurkowiak, Małgorzata
  email: kurkowiak@ibch.poznan.pl
  organization: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznań, Poland. kurkowiak@ibch.poznan.pl
– sequence: 4
  givenname: Kalina
  surname: Wiatr
  fullname: Wiatr, Kalina
  email: kwiatr@ibch.poznan.pl
  organization: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznań, Poland. kwiatr@ibch.poznan.pl
– sequence: 5
  givenname: Maciej
  surname: Figiel
  fullname: Figiel, Maciej
  email: mfigiel@ibch.poznan.pl
  organization: Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznań, Poland. mfigiel@ibch.poznan.pl
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26515641$$D View this record in MEDLINE/PubMed
BookMark eNpdkV1rHSEQhqWkNB_tD8hNEHqTm20dj7puLgoh9AtSSiC9FldnTwy7eqK7Cfn39fSkIe3FoIPvO8zrc0j2YopIyDGwDwBafSywYgIaBrKWYo1-RQ6glapRiqm9F_d9cljKLWOKK5BvyD5XEqQScEDCj7QUpJs0Pl5Rb2fb24Jn1NKIDzTFMUSkGUtaskM6pLxt0GZ3Q5cS4ppOf-xT8jgWmoZqW3Jt1hgx2zncI_WhGgqWt-T1YMeC757OI_Lry-fri2_N5c-v3y_OLxsneDs34BhbOe7Bge6sF70fuFfoOYoeW86kH9qu7WqAduBatFKLrqslGJfS9W51RD7t5m6WfkLvMM7ZjmaTw2Tzo0k2mH9fYrgx63RvhOJSKFkHnD4NyOluwTKbKRSH42gj1rQGWq6V0lpupe__k97Wn4o1XlXVNaFSEVUFO5XLqZSMw_MywMwWpNmBNBWk2YI0unpOXqZ4dvwlt_oNYD2cKg
CitedBy_id crossref_primary_10_3390_ijms20133365
crossref_primary_10_3390_cells11030517
crossref_primary_10_1002_mds_29355
crossref_primary_10_1093_database_baw021
Cites_doi 10.1007/s00335-012-9427-x
10.1093/nar/gkt1196
10.1016/j.tibtech.2013.04.004
10.1016/j.semcdb.2015.03.010
10.1016/0092-8674(93)90585-E
10.1038/ng1196-269
10.1016/j.mcn.2015.03.010
10.1093/nar/gkt977
10.1093/hmg/8.11.2047
10.1038/352077a0
10.1093/hmg/10.14.1441
10.1038/nature05453
10.1038/ng0197-62
10.1016/j.cell.2013.04.025
10.1007/s12035-012-8315-4
10.1093/nar/gkp858
10.1155/2015/873860
10.1038/ng0194-14
10.1101/gr.6.10.965
10.1016/j.nbd.2014.09.020
10.1038/ng1194-221
10.1093/nar/gkr913
10.1038/ng0793-221
10.1038/nm.3617
10.1523/JNEUROSCI.21-15-05389.2001
10.1093/nar/gku967
10.1007/s12035-012-8316-3
10.1038/ng0194-9
10.1093/hmg/ddu532
ContentType Journal Article
Copyright Copyright BioMed Central 2015
Szlachcic et al. 2015
Copyright_xml – notice: Copyright BioMed Central 2015
– notice: Szlachcic et al. 2015
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7TK
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOI 10.1186/s13041-015-0160-8
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Neurosciences Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Databases
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Biological Science Database
Publicly Available Content Database
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1756-6606
EndPage 69
ExternalDocumentID 4016442911
10_1186_s13041_015_0160_8
26515641
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-A0
0R~
123
29M
2WC
3V.
4.4
53G
5VS
7X7
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAJSJ
ABDBF
ABIVO
ABUWG
ACGFO
ACGFS
ACIHN
ACMJI
ACPRK
ACRMQ
ADBBV
ADINQ
ADRAZ
ADUKV
AEAQA
AENEX
AFKRA
AHBYD
AHMBA
AHSBF
AHYZX
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMTXH
AOIJS
BAPOH
BAWUL
BBNVY
BCNDV
BENPR
BFQNJ
BHPHI
BMC
BPHCQ
BVXVI
C24
C6C
CCPQU
CGR
CS3
CUY
CVF
DIK
E3Z
EBD
EBLON
EBS
ECM
EIF
EJD
EMOBN
ESX
F5P
FYUFA
GROUPED_DOAJ
GX1
H13
HCIFZ
HH5
HMCUK
HYE
IAO
IEA
IHR
INH
INR
ITC
KQ8
LK8
M1P
M48
M7P
ML0
M~E
NPM
O5R
O5S
OK1
P2P
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
RBZ
RNS
ROL
RPM
RSV
SBL
SOJ
SV3
TR2
TUS
UKHRP
ZBA
~8M
AAYXX
CITATION
7TK
7XB
8FK
AZQEC
DWQXO
GNUQQ
K9.
PQEST
PQUKI
PRINS
7X8
5PM
AFPKN
ID FETCH-LOGICAL-c427t-1c003c2d1c189ad4bdf2d6ed2e4be7205df79796517f28475849984940255cbc3
IEDL.DBID RPM
ISSN 1756-6606
IngestDate Tue Sep 17 21:22:51 EDT 2024
Fri Oct 25 01:09:38 EDT 2024
Thu Oct 10 17:33:24 EDT 2024
Thu Nov 21 22:40:09 EST 2024
Tue Oct 15 23:54:55 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c427t-1c003c2d1c189ad4bdf2d6ed2e4be7205df79796517f28475849984940255cbc3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625465/
PMID 26515641
PQID 1779711604
PQPubID 54872
PageCount 1
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_4625465
proquest_miscellaneous_1728668855
proquest_journals_1779711604
crossref_primary_10_1186_s13041_015_0160_8
pubmed_primary_26515641
PublicationCentury 2000
PublicationDate 2015-10-29
PublicationDateYYYYMMDD 2015-10-29
PublicationDate_xml – month: 10
  year: 2015
  text: 2015-10-29
  day: 29
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Molecular brain
PublicationTitleAlternate Mol Brain
PublicationYear 2015
Publisher BioMed Central
Publisher_xml – name: BioMed Central
References 8136826 - Nat Genet. 1994 Jan;6(1):14-8
25846864 - Semin Cell Dev Biol. 2015 Apr;40:127-33
25931812 - Drug Des Devel Ther. 2015;9:2179-88
8896555 - Nat Genet. 1996 Nov;14(3):269-76
1853757 - Adv Neurol. 1991;56:209-13
22956270 - Mol Neurobiol. 2012 Oct;46(2):393-429
2062380 - Nature. 1991 Jul 4;352(6330):77-9
11448935 - Hum Mol Genet. 2001 Jul 1;10(14):1441-8
25301414 - Neurobiol Dis. 2015 Jan;73:174-88
25873774 - Mediators Inflamm. 2015;2015:873860
7874163 - Nat Genet. 1994 Nov;8(3):221-8
19854944 - Nucleic Acids Res. 2010 Jan;38(Database issue):D492-6
24316576 - Nucleic Acids Res. 2014 Jan;42(Database issue):D749-55
22940749 - Mamm Genome. 2012 Oct;23(9-10):632-40
23664777 - Trends Biotechnol. 2013 Jul;31(7):397-405
8908515 - Genome Res. 1996 Oct;6(10):965-71
17151600 - Nature. 2007 Jan 11;445(7124):168-76
24194600 - Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
11466410 - J Neurosci. 2001 Aug 1;21(15):5389-96
10484774 - Hum Mol Genet. 1999 Oct;8(11):2047-53
8358429 - Nat Genet. 1993 Jul;4(3):221-6
8136840 - Nat Genet. 1994 Jan;6(1):9-13
25320121 - Hum Mol Genet. 2015 Mar 1;24(5):1211-24
25038828 - Nat Med. 2014 Aug;20(8):881-5
25348401 - Nucleic Acids Res. 2015 Jan;43(Database issue):D726-36
8458085 - Cell. 1993 Mar 26;72(6):971-83
8988170 - Nat Genet. 1997 Jan;15(1):62-9
22064864 - Nucleic Acids Res. 2012 Jan;40(Database issue):D1077-81
22944909 - Mol Neurobiol. 2012 Oct;46(2):430-66
25771431 - Mol Cell Neurosci. 2015 May;66(Pt A):53-61
23643243 - Cell. 2013 May 9;153(4):910-8
R Chang (160_CR16) 2015; 9
M Fernández-Nogales (160_CR29) 2014; 20
BO Evert (160_CR28) 2001; 21
M Kapushesky (160_CR25) 2012; 40
K Lindblad (160_CR6) 1996; 6
S Nagafuchi (160_CR10) 1994; 6
K Nakamura (160_CR8) 2001; 10
B Ramani (160_CR13) 2015; 24
M Figiel (160_CR19) 2012; 46
PM Switonski (160_CR20) 2012; 46
G Koscielny (160_CR31) 2014; 42
R Koide (160_CR9) 1994; 6
Y Kawaguchi (160_CR4) 1994; 8
LY Geer (160_CR27) 2010; 38
PM Switonski (160_CR14) 2015; 73
R Koide (160_CR7) 1999; 8
T Gaj (160_CR21) 2013; 31
H Wang (160_CR22) 2013; 153
P Flicek (160_CR26) 2014; 42
SDM Brown (160_CR30) 2012; 23
JT Eppig (160_CR23) 2015; 43
HT Orr (160_CR2) 1993; 4
SM Pulst (160_CR3) 1996; 14
O Zhuchenko (160_CR5) 1997; 15
KH Fischbeck (160_CR11) 1991; 56
CJ Cortes (160_CR18) 2015; 66
P Egorova (160_CR17) 2015; 40
The Huntington’s Disease Collaborative Research Group (160_CR1) 1993; 72
ES Lein (160_CR24) 2007; 445
AR Spada La (160_CR12) 1991; 352
M Olejniczak (160_CR15) 2015; 2015
References_xml – volume: 23
  start-page: 632
  year: 2012
  ident: 160_CR30
  publication-title: Mamm Genome Off J Int Mamm Genome Soc
  doi: 10.1007/s00335-012-9427-x
  contributor:
    fullname: SDM Brown
– volume: 42
  start-page: D749
  year: 2014
  ident: 160_CR26
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt1196
  contributor:
    fullname: P Flicek
– volume: 31
  start-page: 397
  year: 2013
  ident: 160_CR21
  publication-title: Trends Biotechnol
  doi: 10.1016/j.tibtech.2013.04.004
  contributor:
    fullname: T Gaj
– volume: 40
  start-page: 127
  year: 2015
  ident: 160_CR17
  publication-title: Semin Cell Dev Biol
  doi: 10.1016/j.semcdb.2015.03.010
  contributor:
    fullname: P Egorova
– volume: 72
  start-page: 971
  year: 1993
  ident: 160_CR1
  publication-title: Cell
  doi: 10.1016/0092-8674(93)90585-E
  contributor:
    fullname: The Huntington’s Disease Collaborative Research Group
– volume: 14
  start-page: 269
  year: 1996
  ident: 160_CR3
  publication-title: Nat Genet
  doi: 10.1038/ng1196-269
  contributor:
    fullname: SM Pulst
– volume: 66
  start-page: 53
  issue: Pt A
  year: 2015
  ident: 160_CR18
  publication-title: Mol Cell Neurosci
  doi: 10.1016/j.mcn.2015.03.010
  contributor:
    fullname: CJ Cortes
– volume: 42
  start-page: D802
  year: 2014
  ident: 160_CR31
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkt977
  contributor:
    fullname: G Koscielny
– volume: 8
  start-page: 2047
  year: 1999
  ident: 160_CR7
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/8.11.2047
  contributor:
    fullname: R Koide
– volume: 352
  start-page: 77
  year: 1991
  ident: 160_CR12
  publication-title: Nature
  doi: 10.1038/352077a0
  contributor:
    fullname: AR Spada La
– volume: 10
  start-page: 1441
  year: 2001
  ident: 160_CR8
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/10.14.1441
  contributor:
    fullname: K Nakamura
– volume: 445
  start-page: 168
  year: 2007
  ident: 160_CR24
  publication-title: Nature
  doi: 10.1038/nature05453
  contributor:
    fullname: ES Lein
– volume: 15
  start-page: 62
  year: 1997
  ident: 160_CR5
  publication-title: Nat Genet
  doi: 10.1038/ng0197-62
  contributor:
    fullname: O Zhuchenko
– volume: 9
  start-page: 2179
  year: 2015
  ident: 160_CR16
  publication-title: Drug Des Devel Ther
  contributor:
    fullname: R Chang
– volume: 153
  start-page: 910
  year: 2013
  ident: 160_CR22
  publication-title: Cell
  doi: 10.1016/j.cell.2013.04.025
  contributor:
    fullname: H Wang
– volume: 46
  start-page: 393
  year: 2012
  ident: 160_CR19
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-012-8315-4
  contributor:
    fullname: M Figiel
– volume: 38
  start-page: D492
  issue: Database issue
  year: 2010
  ident: 160_CR27
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkp858
  contributor:
    fullname: LY Geer
– volume: 2015
  start-page: 873860
  year: 2015
  ident: 160_CR15
  publication-title: Mediators Inflamm
  doi: 10.1155/2015/873860
  contributor:
    fullname: M Olejniczak
– volume: 6
  start-page: 14
  year: 1994
  ident: 160_CR10
  publication-title: Nat Genet
  doi: 10.1038/ng0194-14
  contributor:
    fullname: S Nagafuchi
– volume: 6
  start-page: 965
  year: 1996
  ident: 160_CR6
  publication-title: Genome Res
  doi: 10.1101/gr.6.10.965
  contributor:
    fullname: K Lindblad
– volume: 73
  start-page: 174
  year: 2015
  ident: 160_CR14
  publication-title: Neurobiol Dis
  doi: 10.1016/j.nbd.2014.09.020
  contributor:
    fullname: PM Switonski
– volume: 8
  start-page: 221
  year: 1994
  ident: 160_CR4
  publication-title: Nat Genet
  doi: 10.1038/ng1194-221
  contributor:
    fullname: Y Kawaguchi
– volume: 40
  start-page: D1077
  issue: Database issue
  year: 2012
  ident: 160_CR25
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkr913
  contributor:
    fullname: M Kapushesky
– volume: 4
  start-page: 221
  year: 1993
  ident: 160_CR2
  publication-title: Nat Genet
  doi: 10.1038/ng0793-221
  contributor:
    fullname: HT Orr
– volume: 20
  start-page: 881
  year: 2014
  ident: 160_CR29
  publication-title: Nat Med
  doi: 10.1038/nm.3617
  contributor:
    fullname: M Fernández-Nogales
– volume: 21
  start-page: 5389
  year: 2001
  ident: 160_CR28
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.21-15-05389.2001
  contributor:
    fullname: BO Evert
– volume: 56
  start-page: 209
  year: 1991
  ident: 160_CR11
  publication-title: Adv Neurol
  contributor:
    fullname: KH Fischbeck
– volume: 43
  start-page: D726
  issue: Database issue
  year: 2015
  ident: 160_CR23
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gku967
  contributor:
    fullname: JT Eppig
– volume: 46
  start-page: 430
  year: 2012
  ident: 160_CR20
  publication-title: Mol Neurobiol
  doi: 10.1007/s12035-012-8316-3
  contributor:
    fullname: PM Switonski
– volume: 6
  start-page: 9
  year: 1994
  ident: 160_CR9
  publication-title: Nat Genet
  doi: 10.1038/ng0194-9
  contributor:
    fullname: R Koide
– volume: 24
  start-page: 1211
  year: 2015
  ident: 160_CR13
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddu532
  contributor:
    fullname: B Ramani
SSID ssj0062615
Score 2.1293983
Snippet The polyglutamine (polyQ) family of disorders comprises 9 genetic diseases, including several types of ataxia and Huntington disease. Approximately two decades...
Background The polyglutamine (polyQ) family of disorders comprises 9 genetic diseases, including several types of ataxia and Huntington disease. Approximately...
BACKGROUNDThe polyglutamine (polyQ) family of disorders comprises 9 genetic diseases, including several types of ataxia and Huntington disease. Approximately...
SourceID pubmedcentral
proquest
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 69
SubjectTerms Animals
Databases, Protein
Disease Models, Animal
Internet
Mice
Neurodegenerative Diseases - pathology
Peptides - metabolism
Phenotype
Search Engine
User-Computer Interface
SummonAdditionalLinks – databaseName: ProQuest Databases
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NTxQxFH_B5eLFoCiMoqkJ8WDSMO20ndaLAQIhJhAlknBr5qMDJDC7MsuB_973Ot3F1cRzZ9LJ-7Xve34PYNd2qqmb2vFO65qjvRbcaql4Z3LX5FVRq4r-Rj49MycX6tulvkwJtyG1VS50YlTU7bShHPmeKEtXCmFy9XX2i9PUKKquphEaz2BdisLaCawfHJ19P1_oYvTWhU61TGHN3oAaW1H4TA1rJud21Rr942L-3Sn5h-k53oAXyWdk-yPIL2Et9K9gc7_HePnukX1isYszpsc34eYUQ_nAZtPbxx-M2j_JTH1hFUP3mY20GOw-pewZOqwssf1cM-qAv2J38fU4H2dg045Fvss2XEV2alKNLJV0htdwcXz08_CEp3EKvFGynHPR4A1uZCsaYV3VqrrtZGtCK4OqQylz3XYoYme0KDsyWuiaYCymnKKwAwEt3sCkn_ZhG1iBXooJRYW31ylVGtdZrStbERdMHUSeweeFWP1sZM3wMdqwxo8YeMTAEwbeZrCzELxPF2jwT3Bn8HG5jEef6hlVH1AYnkZrGWNx6wy2RpyWu0ka8W6UyKBcQXD5ANFqr670N9eRXlsZmhGg3_7_s97Bc0nnCM2YdDswmd8_hPfon8zrD-kQ_gbXIObV
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3faxQxEB5q--KLqG11tZUpSB8K0U0uySaClCKWIpwgeNC3sD-ybaHdq3cneP-9M9m9w9O--Jzdze5MJvNNZnY-gLeu1XVVV160xlSC_LUUzigtWpv7Oi9HlS75b-TxV3sx0V8uzeUWrOitBgHOHwztmE9qMrt99-vH8pQM_mMyeGffz2kf1hwUcxmazYV7BDuKHCNXeI31OqlA0D0RGpDDtMIScB-SnA8-YtNN_YM9_y6h_MMnnT-FJwOYxLNe-89gK3bPYfeso0D6bonHmMo707n5LtyMKcaPeD-9XX5Drgtl__UBSyRcjX2_DJwNZ_lISBaHNkDXyKXxV3iXbk_EOXOctpgaYTbxKrWt5j0Th1zPfA8m55-_f7oQA8-CqLUqFkLWZNq1amQtnS8bXTWtamxsVNRVLFRumrbwhbdGFi17M8IsFKRprzkeIU2P9mG7m3bxJeCI4IuNo5LM2mtdWN86Y0pXcpOYKso8g5OVWMN9304jpDDE2dDrIJAOAusguAwOVoIPq4URZEHvImlcZ3C0Hiab4ERH2UUSRmDOLWsdTZ3Bi15P69kUc79bLTMoNjS4voD7bW-OdDfXqe-2tkweYF79zze8hseKVxV5O-UPYHsx-xkPCcYsqjdpcf4GoGvtxQ
  priority: 102
  providerName: Scholars Portal
Title Mouse polyQ database: a new online resource for research using mouse models of neurodegenerative diseases
URI https://www.ncbi.nlm.nih.gov/pubmed/26515641
https://www.proquest.com/docview/1779711604
https://search.proquest.com/docview/1728668855
https://pubmed.ncbi.nlm.nih.gov/PMC4625465
Volume 8
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV07b9swED4k6dKlaJs-lKQGCxQdCigWaT67uUGCwICD9BHAGyFSVGIglo3YHfLvc6Qko263LtJAERTujrw78uN3AJ90zb3zzuS1EC5Hf01zLRjPa1kYX5Qjx8t4G3l6JS9v-GQmZnsg-rswCbTv3fy0uV-cNvO7hK1cLfywx4kNr6dnXEYWdzHch310v32K3i6_GKBT0R1fUi2Ha1ykecyYI0ZNFnks0Mdi_W_J6a4v-ifA_Bsn-YfjuXgJL7qIkYzbP3sFe6F5DYfjBrPlxSP5TBKGM22OH8J8iol8IKvl_eN3EsGf0Ul9JSXB4Jm0pBjkoduwJxiuko7r545E_PstWaTuqTrOmixrktguq3CbuKnjwki6A531G7i5OP91dpl3xRRyz5na5NTj_PWsop5qU1bcVTWrZKhY4C4oVoiqVkYZlIyqo8vCwAQzMW54TDpQnaO3cNAsm_AeyAhjFBlGJc5dw7mSptZClLqMTDAu0CKDL71Y7arlzLAp19DStuqwqA4b1WF1Bie94G03fdaWKvwXiu08g4_bZjT8eJpRNgGFYWNhLSk1Dp3Bu1ZP29F6BWegdjS4_SCSau-2oK0lcu3Oto7-u-cxPGfR2tC_MXMCB5uH3-EDBi4bN0BznakBPBuPJz8n-P52fnX9Y5C2AfA55XqQTPkJQ1X0PQ
link.rule.ids 230,314,727,780,784,864,885,12056,21388,24318,27924,27925,31719,31720,33744,33745,43310,43805,53791,53793
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7B9gAXBJRHaAEjIQ5IVmOv7dhcUEGtFuiuALVSb1YeTluJZrfNcui_Z8bxLixInJ3I0Xz2vPMNwGvbqrqqK8dbrSuO9lpwq6XircldnZfjSpX0N_J0ZiYn6vOpPk0Jtz61Va50YlTUzbymHPmeKApXCGFy9X5xxWlqFFVX0wiN27BFzOl6BFsfDmZfv690MXrrQqdaprBmr0eNrSh8poY1k3O7aY3-cTH_7pT8w_Qc3od7yWdk-wPID-BW6B7C9n6H8fLlDXvDYhdnTI9vw8UUQ_nAFvMfN98YtX-SmXrHSobuMxtoMdh1StkzdFhZYvs5Z9QBf8Yu4-txPk7P5i2LfJdNOIvs1KQaWSrp9I_g5PDg-OOEp3EKvFayWHJR4w2uZSNqYV3ZqKppZWNCI4OqQiFz3bQoYme0KFoyWuiaYCymnKKwAwEdP4ZRN-_CU2Bj9FJMGJd4e51ShXGt1bq0JXHBVEHkGbxdidUvBtYMH6MNa_yAgUcMPGHgbQa7K8H7dIF6_xvuDF6tl_HoUz2j7AIKw9NoLWMsbp3BkwGn9W6SRrwbJTIoNhBcP0C02psr3cV5pNdWhmYE6Gf__6yXcGdyPD3yR59mX3bgrqQzhSZNul0YLa9_hufoqyyrF-lA_gLDt-m9
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Nb9QwELWgSIgLKpSP0AJGQhyQ0sSO7djcqsKqfGxVJCr1ZsWO3a7Uza66y6H_nhknWXXhxtmxbHnGnjf2yxtC3usovPPO5FFKl0O8ZrmWXORRlcaXTeVEg38jT0_Vybn4diEv7pT6SqR972aH3fX8sJtdJW7lcu6LkSdWnE2PhUIVd1ks21jcJw9kBU42Jur9IQwwncnhEZNpVazgqBaYNyNTTZU5lunjWAVcCbYdkf6BmX-zJe-En8kueTzgRnrUz-8JuRe6p2TvqIOceX5LP9DE5ExX5HtkNoV0PtDl4vr2J0UKKIaqT7ShAKFpL41Bb4ZrewqglQ6KP1cUWfCXdJ66pxo5K7qINGletuEyKVTj8UiHZ53VM3I--fLr-CQfSirkXvB6nTMPu9jzlnmmTdMK10beqtDyIFyoeSnbWJvawMrUEQMXwBPIx4QRmHqAUavnZKdbdOEloRUgFRWqBnawEaJWJmopG92gHowLrMzIx3FZ7bJXzrAp49DK9uawYA6L5rA6IwfjwtthE60sq2EuDNpFRt5tmsH98U2j6QIshsXyWkppGDojL3o7bUYbDZyResuCmw9QWnu7BTwuSWwPHvbqv3u-JQ_PPk_sj6-n3_fJI46OBwGPmwOys775HV4Dklm7N8ln_wBk5_LJ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mouse+polyQ+database%3A+a+new+online+resource+for+research+using+mouse+models+of+neurodegenerative+diseases&rft.jtitle=Molecular+brain&rft.au=Szlachcic%2C+Wojciech+J.&rft.au=Switonski%2C+Pawel+M.&rft.au=Kurkowiak%2C+Ma%C5%82gorzata&rft.au=Wiatr%2C+Kalina&rft.date=2015-10-29&rft.issn=1756-6606&rft.eissn=1756-6606&rft.volume=8&rft.issue=1&rft_id=info:doi/10.1186%2Fs13041-015-0160-8&rft.externalDBID=n%2Fa&rft.externalDocID=10_1186_s13041_015_0160_8
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1756-6606&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1756-6606&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1756-6606&client=summon