Determination of olanzapine in plasma by high-performance liquid chromatography using ultraviolet absorbance detection

• Published in: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 773; no. 2; pp. 191 - 197
• Main Authors: Dusci, Leon J., Peter Hackett, L., Fellows, Linda M., Ilett, Kenneth F.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.06.2002
• Subjects: Antipsychotic Agents - blood; Benzodiazepines; Chromatography, High Pressure Liquid - methods; Humans; Olanzapine; Pirenzepine - analogs & derivatives; Pirenzepine - blood; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet - methods; Olanzapine

A rapid method for the determination of olanzapine in plasma using high-performance liquid chromatography with ultra violet detection is described. Olanzapine was extracted from plasma with a mixture of hexane/dichloromethane (85:15), and then back extracted into phosphate buffer pH 2.8. Separation...