Evaluation of the pharmacokinetics of posaconazole and rifabutin following co-administration to healthy men

• Published in: Current medical research and opinion Vol. 23; no. 3; pp. 545 - 552
• Main Authors: Krishna, G., Parsons, A., Kantesaria, B., Mant, T.
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.03.2007; Taylor & Francis; Informa Healthcare
• Subjects: Administration, Oral; Adult; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - pharmacokinetics; Antifungal Agents - administration & dosage; Antifungal Agents - pharmacokinetics; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug interaction; Drug Interactions; Evaluation Studies as Topic; Humans; Male; Pharmacokinetics; Posaconazole; Prospective Studies; Reference Values; Rifabutin; Rifabutin - administration & dosage; Rifabutin - adverse effects; Rifabutin - pharmacokinetics; Risk Assessment; Safety; Sensitivity and Specificity; Triazoles - administration & dosage; Triazoles - adverse effects; Triazoles - pharmacokinetics

ABSTRACT Objective: Posaconazole is a triazole antifungal agent for the treatment and prophylaxis of invasive fungal infections. This non-randomized, open-label, parallel-group, multiple-dose, drug-interaction study was conducted to evaluate the pharmacokinetics of posaconazole and rifabutin followi...