Optimised prevention of postnatal HIV transmission in Zambia and Burkina Faso (PROMISE-EPI): a phase 3, open-label, randomised controlled trial

• Published in: The Lancet (British edition) Vol. 403; no. 10434; pp. 1362 - 1371
• Main Authors: Kankasa, Chipepo, Mennecier, Anaïs, Sakana, Beninwendé L D, Molès, Jean-Pierre, Mwiya, Mwiya, Chunda-Liyoka, Catherine, D'Ottavi, Morgana, Tassembedo, Souleymane, Wilfred-Tonga, Maria M, Fao, Paulin, Rutagwera, David, Matoka, Beauty, Kania, Dramane, Taofiki, Ousmane A, Tylleskär, Thorkild, Van de Perre, Philippe, Nagot, Nicolas
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 06.04.2024; Elsevier Limited; Elsevier
• Subjects: Acquired immune deficiency syndrome; Age; AIDS; Antiretroviral agents; Antiretroviral therapy; Babies; Breast feeding; Breastfeeding & lactation; Children & youth; Disease prevention; Disease transmission; Drug therapy; Health care; Health care facilities; HIV; Human health and pathology; Human immunodeficiency virus; Immunization; Immunology; Infants; Infections; Infectious diseases; Intervention; Labels; Lamivudine; Life Sciences; Low income groups; Medical tests; Mothers; Pediatrics; Point of care testing; Pregnancy; Prevention; Prophylaxis; Zambia; Burkina Faso; Africa

Transmission through breastfeeding accounts for more than half of the unacceptably high number of new paediatric HIV infections worldwide. We hypothesised that, in addition to maternal antiretroviral therapy (ART), extended postnatal prophylaxis with lamivudine, guided by point-of-care assays for ma...