Aortic valve sclerosis is an echocardiographic indicator of significant coronary disease in patients undergoing diagnostic coronary angiography
Summary Aortic valve sclerosis (AVS) is considered to be a manifestation of generalised atherosclerosis that involves the aortic valve. It has been associated with higher cardiovascular morbidity and mortality in a population‐based study. This investigation used transthoracic echocardiography (TTE)...
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Published in | International journal of clinical practice (Esher) Vol. 59; no. 1; pp. 72 - 77 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Oxford, UK; Malden, USA
Blackwell Science Ltd
01.01.2005
Blackwell Hindawi Limited |
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Abstract | Summary
Aortic valve sclerosis (AVS) is considered to be a manifestation of generalised atherosclerosis that involves the aortic valve. It has been associated with higher cardiovascular morbidity and mortality in a population‐based study. This investigation used transthoracic echocardiography (TTE) to evaluate the prevalence and significance of AVS in 357 Chinese patients with suspected coronary artery disease (CAD). This work reveals that AVS is an independent echocardiographic predictor of significant CAD in such clinical setting (O.R. = 3.18; 95% confidence interval 1.52–6.7; p = 0.002). Other independent predictors include male gender, diabetes mellitus and hypertriglyceridemia. The predictive value of AVS for the presence of CAD is more prominent in females and in subjects aged <65 years. The recognition of AVS on TTE should alert the physicians to the possibility of underlying significant CAD, and further evaluation with aggressive management is indicated, even though no angiographic documentation is available. |
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AbstractList | Summary
Aortic valve sclerosis (AVS) is considered to be a manifestation of generalised atherosclerosis that involves the aortic valve. It has been associated with higher cardiovascular morbidity and mortality in a population‐based study. This investigation used transthoracic echocardiography (TTE) to evaluate the prevalence and significance of AVS in 357 Chinese patients with suspected coronary artery disease (CAD). This work reveals that AVS is an independent echocardiographic predictor of significant CAD in such clinical setting (O.R. = 3.18; 95% confidence interval 1.52–6.7; p = 0.002). Other independent predictors include male gender, diabetes mellitus and hypertriglyceridemia. The predictive value of AVS for the presence of CAD is more prominent in females and in subjects aged <65 years. The recognition of AVS on TTE should alert the physicians to the possibility of underlying significant CAD, and further evaluation with aggressive management is indicated, even though no angiographic documentation is available. Aortic valve sclerosis (AVS) is considered to be a manifestation of generalised atherosclerosis that involves the aortic valve. It has been associated with higher cardiovascular morbidity and mortality in a population-based study. This investigation used transthoracic echocardiography (TTE) to evaluate the prevalence and significance of AVS in 357 Chinese patients with suspected coronary artery disease (CAD). This work reveals that AVS is an independent echocardiographic predictor of significant CAD in such clinical setting (O.R.=3.18; 95% confidence interval 1.52-6.7; p=0.002). Other independent predictors include male gender, diabetes mellitus and hypertriglyceridemia. The predictive value of AVS for the presence of CAD is more prominent in females and in subjects aged <65 years. The recognition of AVS on TTE should alert the physicians to the possibility of underlying significant CAD, and further evaluation with aggressive management is indicated, even though no angiographic documentation is available. Aortic valve sclerosis (AVS) is considered to be a manifestation of generalised atherosclerosis that involves the aortic valve. It has been associated with higher cardiovascular morbidity and mortality in a population-based study. This investigation used transthoracic echocardiography (TTE) to evaluate the prevalence and significance of AVS in 357 Chinese patients with suspected coronary artery disease (CAD). This work reveals that AVS is an independent echocardiographic predictor of significant CAD in such clinical setting (O.R. = 3.18; 95% confidence interval 1.52-6.7; p = 0.002). Other independent predictors include male gender, diabetes mellitus and hypertriglyceridemia. The predictive value of AVS for the presence of CAD is more prominent in females and in subjects aged <65 years. The recognition of AVS on TTE should alert the physicians to the possibility of underlying significant CAD, and further evaluation with aggressive management is indicated, even though no angiographic documentation is available. [PUBLICATION ABSTRACT] Aortic valve sclerosis (AVS) is considered to be a manifestation of generalised atherosclerosis that involves the aortic valve. It has been associated with higher cardiovascular morbidity and mortality in a population-based study. This investigation used transthoracic echocardiography (TTE) to evaluate the prevalence and significance of AVS in 357 Chinese patients with suspected coronary artery disease (CAD). This work reveals that AVS is an independent echocardiographic predictor of significant CAD in such clinical setting (O.R.=3.18; 95% confidence interval 1.52-6.7; p=0.002). Other independent predictors include male gender, diabetes mellitus and hypertriglyceridemia. The predictive value of AVS for the presence of CAD is more prominent in females and in subjects aged <65 years. The recognition of AVS on TTE should alert the physicians to the possibility of underlying significant CAD, and further evaluation with aggressive management is indicated, even though no angiographic documentation is available. |
Author | Chang, S-H. Hsu, S-Y. Hung, K-C. Hsieh, I-C. Wen, M-S. |
Author_xml | – sequence: 1 givenname: S-Y. surname: Hsu fullname: Hsu, S-Y. organization: Section of General Medicine,1Second Section of Cardiology,2Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan – sequence: 2 givenname: I-C. surname: Hsieh fullname: Hsieh, I-C. organization: Section of General Medicine,1Second Section of Cardiology,2Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan – sequence: 3 givenname: S-H. surname: Chang fullname: Chang, S-H. organization: Section of General Medicine,1Second Section of Cardiology,2Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan – sequence: 4 givenname: M-S. surname: Wen fullname: Wen, M-S. organization: Section of General Medicine,1Second Section of Cardiology,2Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan – sequence: 5 givenname: K-C. surname: Hung fullname: Hung, K-C. email: hungkuochun@yahoo.com.tw organization: Section of General Medicine,1Second Section of Cardiology,2Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan |
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CitedBy_id | crossref_primary_10_1097_00000441_200605000_00005 crossref_primary_10_1016_j_ijcard_2013_10_081 crossref_primary_10_1016_j_ijcard_2018_01_054 crossref_primary_10_1177_1753944720985985 crossref_primary_10_1089_ars_2015_6554 crossref_primary_10_1155_2022_2074356 crossref_primary_10_1161_ATVBAHA_118_312233 crossref_primary_10_1016_j_atherosclerosis_2013_05_026 crossref_primary_10_1111_j_1368_5031_2005_00339_x crossref_primary_10_1016_j_echo_2006_11_018 crossref_primary_10_1007_s13239_017_0296_z crossref_primary_10_1586_14779072_2013_811978 crossref_primary_10_15406_jccr_2018_11_00367 crossref_primary_10_1016_j_arcmed_2008_12_003 crossref_primary_10_1111_j_1540_8175_2007_00379_x crossref_primary_10_1371_journal_pone_0020969 |
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References_xml | – volume: 341 start-page: 142 year: 1999 end-page: 7 article-title: Association of aortic valve sclerosis with cardiovascular mortality and morbidity in the elderly publication-title: N Engl J Med – volume: 15 start-page: 865 year: 1994 end-page: 70 article-title: Factors associated with calcific aortic valve degeneration in the elderly publication-title: Eur Heart J – volume: 76 start-page: 928 year: 1995 end-page: 32 article-title: Correlation between lipoprotein(a) and aortic valve sclerosis assessed by echocardiography (the JMS cardiac echo and cohort study) publication-title: Am J Cardiol – volume: 63 start-page: 1 issue: Suppl. year: 1981 end-page: 41 article-title: National Heart, Lung and Blood Institute Coronary Artery Surgery Study publication-title: Circulation – volume: 21 start-page: 1220 year: 1993 end-page: 5 article-title: Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample publication-title: J Am Coll Cardiol – volume: 332 start-page: 1758 year: 1995 end-page: 66 article-title: The primary prevention of coronary heart disease in women publication-title: N Engl J Med – volume: 161 start-page: 193 year: 2002 end-page: 7 article-title: Nonobstructive aortic valve calcification: a window to significant coronary artery disease publication-title: Atherosclerosis – volume: 58 start-page: 572 year: 1986 end-page: 4 article-title: The senile cardiac calcification syndrome publication-title: Am J Cardiol – volume: 38 start-page: 827 year: 2001 end-page: 34 article-title: Aortic valve sclerosis and atherosclerosis: different manifestations of the same disease? 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Aortic valve sclerosis (AVS) is considered to be a manifestation of generalised atherosclerosis that involves the aortic valve. It has been associated... Aortic valve sclerosis (AVS) is considered to be a manifestation of generalised atherosclerosis that involves the aortic valve. It has been associated with... |
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SubjectTerms | Aged Angioplasty Aortic Valve - diagnostic imaging Aortic Valve - pathology Aortic valve sclerosis Biological and medical sciences Cardiac Catheterization - methods Cardiovascular disease Cardiovascular system Clinical outcomes Coronary Angiography - methods coronary artery disease Coronary Artery Disease - diagnostic imaging echocardiography Echocardiography - methods Female General aspects Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical diagnosis Medical sciences Middle Aged Predictive Value of Tests Regression Analysis Retrospective Studies Sclerosis Sensitivity and Specificity Ultrasonic investigative techniques |
Title | Aortic valve sclerosis is an echocardiographic indicator of significant coronary disease in patients undergoing diagnostic coronary angiography |
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