Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity

• Published in: Brain imaging and behavior Vol. 14; no. 5; pp. 1468 - 1476
• Main Authors: Lyall, Donald M., Cox, Simon R., Lyall, Laura M., Celis-Morales, Carlos, Cullen, Breda, Mackay, Daniel F., Ward, Joey, Strawbridge, Rona J., McIntosh, Andrew M., Sattar, Naveed, Smith, Daniel J., Cavanagh, Jonathan, Deary, Ian J., Pell, Jill P.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2020; Springer Nature B.V
• Subjects: Age; Aging; Anisotropy; Apolipoprotein E4; Apolipoprotein E4 - genetics; Biomedical and Life Sciences; Biomedicine; Brain; Brain - diagnostic imaging; Cognitive ability; Confidence intervals; Cross-Sectional Studies; Dementia disorders; Deprivation; Diffusion Tensor Imaging; Genotype & phenotype; Genotypes; Hippocampus; Humans; Integrity; Magnetic Resonance Imaging; Medical imaging; Neuroimaging; Neuropsychology; Neuroradiology; Neurosciences; NMR; Nuclear magnetic resonance; Original Research; Phenotypes; Psychiatry; Risk acceptance; Risk analysis; Smoking; Statistical analysis; Statistical significance; Substantia alba; Substantia grisea; Substrates; United Kingdom; White Matter - diagnostic imaging; United Kingdom; United Kingdom > UK; Aging; Genetic association studies; APOE; MRI; Epidemiology

Apolipoprotein ( APOE ) e4 genotype is an accepted risk factor for accelerated cognitive aging and dementia, though its neurostructural substrates are unclear. The deleterious effects of this genotype on brain structure may increase in magnitude into older age. This study aimed to investigate in UK...