General and social anxiety in the BTBR T+ tf/J mouse strain
▶ BTBR showed enhanced anxiety in the EPM and MDTB. ▶ BTBR showed reduced anxiety in the zero-maze. ▶ BTBR showed enhanced defensiveness or anxiety-like response to another mouse. ▶ Diazepam normalized the social preference of BTBR mice. BTBR T+ tf/J (BTBR) is an inbred mouse strain that shows behav...
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| Published in | Behavioural brain research Vol. 216; no. 1; pp. 446 - 451 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier B.V
01.01.2011
Elsevier |
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| Online Access | Get full text |
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| Abstract | ▶ BTBR showed enhanced anxiety in the EPM and MDTB. ▶ BTBR showed reduced anxiety in the zero-maze. ▶ BTBR showed enhanced defensiveness or anxiety-like response to another mouse. ▶ Diazepam normalized the social preference of BTBR mice.
BTBR T+ tf/J (BTBR) is an inbred mouse strain that shows behavioral traits with analogies to the three diagnostic symptoms of autism spectrum disorder (ASD); deficits in social interaction, impaired communication, and repetitive behaviors with restricted interests. Previous findings reveal that when compared to C57BL/6J (B6) and other inbred strains, BTBR exhibit normal to low anxiety-like traits in paradigms designed to assess anxiety-related behaviors. The current study assessed the generality of these anxiety findings. In experiment 1, B6 and BTBR mice were tested in the elevated plus maze (EPM), mouse defense test battery (MDTB) and elevated zero-maze. BTBR mice exhibited an anxiogenic profile in the EPM, with a reduction in open arm time and an increase in risk assessment behaviors, as compared to B6. In the MDTB, BTBR showed enhanced vocalization to the predator, and significantly less locomotor activity than B6 in the pre-threat situation, but significantly more locomotion than B6 following exposure to a predator threat, suggesting enhanced defensiveness to the predator. In the zero-maze, BTBR mice showed a significantly higher number of entries and time spent in the open segments of the apparatus, when compared to B6. In experiment 2, a three-chambered social preference test was used to evaluate effects of the systemic administration of an anxiolytic compound, diazepam, on B6 and BTBR social approach. Diazepam consistently increased time in the compartment containing the social stimulus, for both B6 and BTBR mice. However, in the vehicle treated groups, B6 mice spent significantly more time while BTBR mice spent significantly less time in the social stimulus compartment; after diazepam administration both B6 and BTBR strains significantly preferred the social stimulus chamber. These results suggest that while the anxiety responses of BTBR mice to novel situations (EPM and zero-maze) are inconsistent, BTBR mice appear to be more defensive to animate threat stimuli (predator or another mouse). Reduction of anxiety by diazepam normalized the social preference of BTBR for a mouse stimulus in the three-chambered test. |
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| AbstractList | BTBR T+ tf/J (BTBR) is an inbred mouse strain that shows behavioral traits with analogies to the three diagnostic symptoms of autism spectrum disorder (ASD); deficits in social interaction, impaired communication, and repetitive behaviors with restricted interests. Previous findings reveal that when compared to C57BL/6J (B6) and other inbred strains, BTBR exhibit normal to low anxiety-like traits in paradigms designed to assess anxiety-related behaviors. The current study assessed the generality of these anxiety findings. In experiment 1, B6 and BTBR mice were tested in the elevated plus maze (EPM), mouse defense test battery (MDTB) and elevated zero-maze. BTBR mice exhibited an anxiogenic profile in the EPM, with a reduction in open arm time and an increase in risk assessment behaviors, as compared to B6. In the MDTB, BTBR showed enhanced vocalization to the predator, and significantly less locomotor activity than B6 in the pre-threat situation, but significantly more locomotion than B6 following exposure to a predator threat, suggesting enhanced defensiveness to the predator. In the zero-maze, BTBR mice showed a significantly higher number of entries and time spent in the open segments of the apparatus, when compared to B6. In experiment 2, a three-chambered social preference test was used to evaluate effects of the systemic administration of an anxiolytic compound, diazepam, on B6 and BTBR social approach. Diazepam consistently increased time in the compartment containing the social stimulus, for both B6 and BTBR mice. However, in the vehicle treated groups, B6 mice spent significantly more time while BTBR mice spent significantly less time in the social stimulus compartment; after diazepam administration both B6 and BTBR strains significantly preferred the social stimulus chamber. These results suggest that while the anxiety responses of BTBR mice to novel situations (EPM and zero-maze) are inconsistent, BTBR mice appear to be more defensive to animate threat stimuli (predator or another mouse). Reduction of anxiety by diazepam normalized the social preference of BTBR for a mouse stimulus in the three-chambered test.BTBR T+ tf/J (BTBR) is an inbred mouse strain that shows behavioral traits with analogies to the three diagnostic symptoms of autism spectrum disorder (ASD); deficits in social interaction, impaired communication, and repetitive behaviors with restricted interests. Previous findings reveal that when compared to C57BL/6J (B6) and other inbred strains, BTBR exhibit normal to low anxiety-like traits in paradigms designed to assess anxiety-related behaviors. The current study assessed the generality of these anxiety findings. In experiment 1, B6 and BTBR mice were tested in the elevated plus maze (EPM), mouse defense test battery (MDTB) and elevated zero-maze. BTBR mice exhibited an anxiogenic profile in the EPM, with a reduction in open arm time and an increase in risk assessment behaviors, as compared to B6. In the MDTB, BTBR showed enhanced vocalization to the predator, and significantly less locomotor activity than B6 in the pre-threat situation, but significantly more locomotion than B6 following exposure to a predator threat, suggesting enhanced defensiveness to the predator. In the zero-maze, BTBR mice showed a significantly higher number of entries and time spent in the open segments of the apparatus, when compared to B6. In experiment 2, a three-chambered social preference test was used to evaluate effects of the systemic administration of an anxiolytic compound, diazepam, on B6 and BTBR social approach. Diazepam consistently increased time in the compartment containing the social stimulus, for both B6 and BTBR mice. However, in the vehicle treated groups, B6 mice spent significantly more time while BTBR mice spent significantly less time in the social stimulus compartment; after diazepam administration both B6 and BTBR strains significantly preferred the social stimulus chamber. These results suggest that while the anxiety responses of BTBR mice to novel situations (EPM and zero-maze) are inconsistent, BTBR mice appear to be more defensive to animate threat stimuli (predator or another mouse). Reduction of anxiety by diazepam normalized the social preference of BTBR for a mouse stimulus in the three-chambered test. BTBR T+ tf/J (BTBR) is an inbred mouse strain that shows behavioral traits with analogies to the three diagnostic symptoms of autism spectrum disorder (ASD); deficits in social interaction, impaired communication, and repetitive behaviors with restricted interests. Previous findings reveal that when compared to C57BL/6J (B6) and other inbred strains, BTBR exhibit normal to low anxiety-like traits in paradigms designed to assess anxiety-related behaviors. The current study assessed the generality of these anxiety findings. In experiment 1, B6 and BTBR mice were tested in the elevated plus maze (EPM), mouse defense test battery (MDTB) and elevated zero-maze. BTBR mice exhibited an anxiogenic profile in the EPM, with a reduction in open arm time and an increase in risk assessment behaviors, as compared to B6. In the MDTB, BTBR showed enhanced vocalization to the predator, and significantly less locomotor activity than B6 in the pre-threat situation, but significantly more locomotion than B6 following exposure to a predator threat, suggesting enhanced defensiveness to the predator. In the zero-maze, BTBR mice showed a significantly higher number of entries and time spent in the open segments of the apparatus, when compared to B6. In experiment 2, a three-chambered social preference test was used to evaluate effects of the systemic administration of an anxiolytic compound, diazepam, on B6 and BTBR social approach. Diazepam consistently increased time in the compartment containing the social stimulus, for both B6 and BTBR mice. However, in the vehicle treated groups, B6 mice spent significantly more time while BTBR mice spent significantly less time in the social stimulus compartment; after diazepam administration both B6 and BTBR strains significantly preferred the social stimulus chamber. These results suggest that while the anxiety responses of BTBR mice to novel situations (EPM and zero-maze) are inconsistent, BTBR mice appear to be more defensive to animate threat stimuli (predator or another mouse). Reduction of anxiety by diazepam normalized the social preference of BTBR for a mouse stimulus in the three-chambered test. ▶ BTBR showed enhanced anxiety in the EPM and MDTB. ▶ BTBR showed reduced anxiety in the zero-maze. ▶ BTBR showed enhanced defensiveness or anxiety-like response to another mouse. ▶ Diazepam normalized the social preference of BTBR mice. BTBR T+ tf/J (BTBR) is an inbred mouse strain that shows behavioral traits with analogies to the three diagnostic symptoms of autism spectrum disorder (ASD); deficits in social interaction, impaired communication, and repetitive behaviors with restricted interests. Previous findings reveal that when compared to C57BL/6J (B6) and other inbred strains, BTBR exhibit normal to low anxiety-like traits in paradigms designed to assess anxiety-related behaviors. The current study assessed the generality of these anxiety findings. In experiment 1, B6 and BTBR mice were tested in the elevated plus maze (EPM), mouse defense test battery (MDTB) and elevated zero-maze. BTBR mice exhibited an anxiogenic profile in the EPM, with a reduction in open arm time and an increase in risk assessment behaviors, as compared to B6. In the MDTB, BTBR showed enhanced vocalization to the predator, and significantly less locomotor activity than B6 in the pre-threat situation, but significantly more locomotion than B6 following exposure to a predator threat, suggesting enhanced defensiveness to the predator. In the zero-maze, BTBR mice showed a significantly higher number of entries and time spent in the open segments of the apparatus, when compared to B6. In experiment 2, a three-chambered social preference test was used to evaluate effects of the systemic administration of an anxiolytic compound, diazepam, on B6 and BTBR social approach. Diazepam consistently increased time in the compartment containing the social stimulus, for both B6 and BTBR mice. However, in the vehicle treated groups, B6 mice spent significantly more time while BTBR mice spent significantly less time in the social stimulus compartment; after diazepam administration both B6 and BTBR strains significantly preferred the social stimulus chamber. These results suggest that while the anxiety responses of BTBR mice to novel situations (EPM and zero-maze) are inconsistent, BTBR mice appear to be more defensive to animate threat stimuli (predator or another mouse). Reduction of anxiety by diazepam normalized the social preference of BTBR for a mouse stimulus in the three-chambered test. a- BTBR showed enhanced anxiety in the EPM and MDTB. a- BTBR showed reduced anxiety in the zero-maze. a- BTBR showed enhanced defensiveness or anxiety-like response to another mouse. a- Diazepam normalized the social preference of BTBR mice. BTBR T+ tf/J (BTBR) is an inbred mouse strain that shows behavioral traits with analogies to the three diagnostic symptoms of autism spectrum disorder (ASD); deficits in social interaction, impaired communication, and repetitive behaviors with restricted interests. Previous findings reveal that when compared to C57BL/6J (B6) and other inbred strains, BTBR exhibit normal to low anxiety-like traits in paradigms designed to assess anxiety-related behaviors. The current study assessed the generality of these anxiety findings. In experiment 1, B6 and BTBR mice were tested in the elevated plus maze (EPM), mouse defense test battery (MDTB) and elevated zero-maze. BTBR mice exhibited an anxiogenic profile in the EPM, with a reduction in open arm time and an increase in risk assessment behaviors, as compared to B6. In the MDTB, BTBR showed enhanced vocalization to the predator, and significantly less locomotor activity than B6 in the pre-threat situation, but significantly more locomotion than B6 following exposure to a predator threat, suggesting enhanced defensiveness to the predator. In the zero-maze, BTBR mice showed a significantly higher number of entries and time spent in the open segments of the apparatus, when compared to B6. In experiment 2, a three-chambered social preference test was used to evaluate effects of the systemic administration of an anxiolytic compound, diazepam, on B6 and BTBR social approach. Diazepam consistently increased time in the compartment containing the social stimulus, for both B6 and BTBR mice. However, in the vehicle treated groups, B6 mice spent significantly more time while BTBR mice spent significantly less time in the social stimulus compartment; after diazepam administration both B6 and BTBR strains significantly preferred the social stimulus chamber. These results suggest that while the anxiety responses of BTBR mice to novel situations (EPM and zero-maze) are inconsistent, BTBR mice appear to be more defensive to animate threat stimuli (predator or another mouse). Reduction of anxiety by diazepam normalized the social preference of BTBR for a mouse stimulus in the three-chambered test. |
| Author | Pobbe, Roger L.H. Defensor, Erwin B. Blanchard, Robert J. Pearson, Brandon L. Blanchard, D. Caroline Bolivar, Valerie J. |
| AuthorAffiliation | d Department of Genetics and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96822, USA b Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA c Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Albany, NY, USA e Department of Psychology, University of Hawaii, 2430 Campus Road, Honolulu, HI 96822, USA a Pacific Biosciences Research Center, University of Hawaii,1993 East-West Road, Honolulu, HI 96822, USA |
| AuthorAffiliation_xml | – name: d Department of Genetics and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96822, USA – name: c Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Albany, NY, USA – name: e Department of Psychology, University of Hawaii, 2430 Campus Road, Honolulu, HI 96822, USA – name: a Pacific Biosciences Research Center, University of Hawaii,1993 East-West Road, Honolulu, HI 96822, USA – name: b Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA |
| Author_xml | – sequence: 1 givenname: Roger L.H. surname: Pobbe fullname: Pobbe, Roger L.H. email: rogerlh@hawaii.edu organization: Pacific Biosciences Research Center, University of Hawaii,1993 East-West Road, Honolulu, HI 96822, USA – sequence: 2 givenname: Erwin B. surname: Defensor fullname: Defensor, Erwin B. organization: Pacific Biosciences Research Center, University of Hawaii,1993 East-West Road, Honolulu, HI 96822, USA – sequence: 3 givenname: Brandon L. surname: Pearson fullname: Pearson, Brandon L. organization: Pacific Biosciences Research Center, University of Hawaii,1993 East-West Road, Honolulu, HI 96822, USA – sequence: 4 givenname: Valerie J. surname: Bolivar fullname: Bolivar, Valerie J. organization: Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA – sequence: 5 givenname: D. Caroline surname: Blanchard fullname: Blanchard, D. Caroline organization: Pacific Biosciences Research Center, University of Hawaii,1993 East-West Road, Honolulu, HI 96822, USA – sequence: 6 givenname: Robert J. surname: Blanchard fullname: Blanchard, Robert J. organization: Pacific Biosciences Research Center, University of Hawaii,1993 East-West Road, Honolulu, HI 96822, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23436848$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/20816701$$D View this record in MEDLINE/PubMed |
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| Keywords | Autism Anxiety Social behavior Mouse models BTBR Affect affectivity Animal model Social phobia Rodentia Anxiety disorder Developmental disorder Vertebrata Mammalia Mouse Social interaction Animal |
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| PublicationTitle | Behavioural brain research |
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| SubjectTerms | Adult and adolescent clinical studies Analysis of Variance Animals Anxiety Anxiety - physiopathology Anxiety disorders. Neuroses Autism Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences BTBR Child clinical studies Developmental disorders Exploratory Behavior - physiology Fundamental and applied biological sciences. Psychology Infantile autism Male Medical sciences Mice Mice, Inbred Strains Motor Activity - physiology Mouse models Phenotype Phobia Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Social Behavior Species Specificity |
| Title | General and social anxiety in the BTBR T+ tf/J mouse strain |
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