Sepiolite, a potential excipient for drugs subject to oxidative degradation

• Published in: Journal of pharmaceutical sciences Vol. 70; no. 2; p. 189
• Main Authors: Hermosin, M C, Cornejo, J, White, J L, Hem, S L
• Format: Journal Article
• Language: English
• Published: United States 01.02.1981
• Subjects: Adsorption; Drug Stability; Excipients; Hydrocortisone - analysis; Hydrogen-Ion Concentration; Kinetics; Magnesium Silicates; Minerals; Oxidation-Reduction; Viscosity

Sepiolite, a member of the fibrous mineral group of clays, is relatively free of surface ferric iron and does not accelerate significantly the oxidative degradation of hydrocortisone. The compatibility of sepiolite with drugs that can undergo oxidative degradation is in sharp contrast to the catalyt...