Sepiolite, a potential excipient for drugs subject to oxidative degradation

Sepiolite, a member of the fibrous mineral group of clays, is relatively free of surface ferric iron and does not accelerate significantly the oxidative degradation of hydrocortisone. The compatibility of sepiolite with drugs that can undergo oxidative degradation is in sharp contrast to the catalyt...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 70; no. 2; p. 189
Main Authors Hermosin, M C, Cornejo, J, White, J L, Hem, S L
Format Journal Article
LanguageEnglish
Published United States 01.02.1981
Subjects
Adsorption
Drug Stability
Excipients
Hydrocortisone - analysis
Hydrogen-Ion Concentration
Kinetics
Magnesium Silicates
Minerals
Oxidation-Reduction
Viscosity
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Summary:Sepiolite, a member of the fibrous mineral group of clays, is relatively free of surface ferric iron and does not accelerate significantly the oxidative degradation of hydrocortisone. The compatibility of sepiolite with drugs that can undergo oxidative degradation is in sharp contrast to the catalytic effect of attapulgite, another fibrous mineral, which contains a significant amount of surface ferric iron and which therefore accelerates oxidative degradation. Sepiolite adsorbs hydrocortisone by a weak adsorption mechanism, which was shown by IR spectroscopy to be chiefly due to hydrogen bonding. However, accelerated oxidative degradation of the adsorbed hydrocortisone does not occur. Maximum adsorption occurs at pH 7-8.5. Desorption occurs readily by washing with water. Sepiolite has similar rheological properties to attapulgite. The results of this study suggest that sepiolite may be useful as a pharmaceutical excipient for drugs that undergo oxidative degradation.
ISSN:0022-3549
DOI:10.1002/jps.2600700219