CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain
The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed to identify dendritic cells in the periphery (Lindquist et al. [2004] Nat. Immunol. 5:1243–1250). In this study, we used this mouse to characterize dendritic cells within the CNS. Our anatomic results showed discre...
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| Published in | Journal of comparative neurology (1911) Vol. 508; no. 5; pp. 687 - 710 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc., A Wiley Company
10.06.2008
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed to identify dendritic cells in the periphery (Lindquist et al. [2004] Nat. Immunol. 5:1243–1250). In this study, we used this mouse to characterize dendritic cells within the CNS. Our anatomic results showed discrete populations of EYFP+ brain dendritic cells (EYFP+ bDC) that colocalized with a small fraction of microglia immunoreactive for Mac‐1, Iba‐1, CD45, and F4/80 but not for NeuN, Dcx, NG2 proteoglycan, or GFAP. EYFP+ bDC, isolated by fluorescent activated cell sorting (FACS), expressed mRNA for the Itgax (CD11c) gene, whereas FACS anlaysis of EYFP+ bDC cultures revealed the presence of CD11c protein. Light microscopy studies revealed that EYFP+ bDC were present in the embryonic CNS when the blood–brain barrier is formed and postnatally when brain cells are amenable to culturing. In adult male mice, EYFP+ bDC distribution was prominent within regions of the CNS that 1) are subject to structural plasticity and neurogenesis, 2) receive sensory and humoral input from the external environment, and 3) lack a blood–brain barrier. Ultrastructural analysis of EYFP+ bDC in adult neurogenic niches showed their proximity to developing neurons and a morphology characteristic of immune/microglia cells. Kainic acid‐induced seizures revealed that EYFP+ bDC responded to damage of the hippocampus and displayed morphologies similar to those described for seizure‐activated EGFP+ microglia in the hippocampus of cfms (CSF‐1R) EGFP mice. Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population. J. Comp. Neurol. 508:687–710, 2008. © 2008 Wiley‐Liss, Inc. |
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| AbstractList | The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed to identify dendritic cells in the periphery (Lindquist et al. [2004] Nat. Immunol. 5:1243–1250). In this study, we used this mouse to characterize dendritic cells within the CNS. Our anatomic results showed discrete populations of EYFP+ brain dendritic cells (EYFP+ bDC) that colocalized with a small fraction of microglia immunoreactive for Mac‐1, Iba‐1, CD45, and F4/80 but not for NeuN, Dcx, NG2 proteoglycan, or GFAP. EYFP+ bDC, isolated by fluorescent activated cell sorting (FACS), expressed mRNA for the Itgax (CD11c) gene, whereas FACS anlaysis of EYFP+ bDC cultures revealed the presence of CD11c protein. Light microscopy studies revealed that EYFP+ bDC were present in the embryonic CNS when the blood–brain barrier is formed and postnatally when brain cells are amenable to culturing. In adult male mice, EYFP+ bDC distribution was prominent within regions of the CNS that 1) are subject to structural plasticity and neurogenesis, 2) receive sensory and humoral input from the external environment, and 3) lack a blood–brain barrier. Ultrastructural analysis of EYFP+ bDC in adult neurogenic niches showed their proximity to developing neurons and a morphology characteristic of immune/microglia cells. Kainic acid‐induced seizures revealed that EYFP+ bDC responded to damage of the hippocampus and displayed morphologies similar to those described for seizure‐activated EGFP+ microglia in the hippocampus of cfms (CSF‐1R) EGFP mice. Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population. J. Comp. Neurol. 508:687–710, 2008. © 2008 Wiley‐Liss, Inc. The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed to identify dendritic cells in the periphery (Lindquist et al. [ 2004 ] Nat. Immunol. 5:1243–1250). In this study, we used this mouse to characterize dendritic cells within the CNS. Our anatomic results showed discrete populations of EYFP + brain dendritic cells (EYFP + bDC) that colocalized with a small fraction of microglia immunoreactive for Mac‐1, Iba‐1, CD45, and F4/80 but not for NeuN, Dcx, NG2 proteoglycan, or GFAP. EYFP + bDC, isolated by fluorescent activated cell sorting (FACS), expressed mRNA for the Itgax (CD11c) gene, whereas FACS anlaysis of EYFP + bDC cultures revealed the presence of CD11c protein. Light microscopy studies revealed that EYFP + bDC were present in the embryonic CNS when the blood–brain barrier is formed and postnatally when brain cells are amenable to culturing. In adult male mice, EYFP + bDC distribution was prominent within regions of the CNS that 1) are subject to structural plasticity and neurogenesis, 2) receive sensory and humoral input from the external environment, and 3) lack a blood–brain barrier. Ultrastructural analysis of EYFP + bDC in adult neurogenic niches showed their proximity to developing neurons and a morphology characteristic of immune/microglia cells. Kainic acid‐induced seizures revealed that EYFP + bDC responded to damage of the hippocampus and displayed morphologies similar to those described for seizure‐activated EGFP + microglia in the hippocampus of cfms (CSF‐1R) EGFP mice. Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population. J. Comp. Neurol. 508:687–710, 2008. © 2008 Wiley‐Liss, Inc. The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed to identify dendritic cells in the periphery (Lindquist et al. [2004] Nat. Immunol. 5:1243-1250). In this study, we used this mouse to characterize dendritic cells within the CNS. Our anatomic results showed discrete populations of EYFP(+) brain dendritic cells (EYFP(+) bDC) that colocalized with a small fraction of microglia immunoreactive for Mac-1, Iba-1, CD45, and F4/80 but not for NeuN, Dcx, NG2 proteoglycan, or GFAP. EYFP(+) bDC, isolated by fluorescent activated cell sorting (FACS), expressed mRNA for the Itgax (CD11c) gene, whereas FACS anlaysis of EYFP(+) bDC cultures revealed the presence of CD11c protein. Light microscopy studies revealed that EYFP(+) bDC were present in the embryonic CNS when the blood-brain barrier is formed and postnatally when brain cells are amenable to culturing. In adult male mice, EYFP(+) bDC distribution was prominent within regions of the CNS that 1) are subject to structural plasticity and neurogenesis, 2) receive sensory and humoral input from the external environment, and 3) lack a blood-brain barrier. Ultrastructural analysis of EYFP(+) bDC in adult neurogenic niches showed their proximity to developing neurons and a morphology characteristic of immune/microglia cells. Kainic acid-induced seizures revealed that EYFP(+) bDC responded to damage of the hippocampus and displayed morphologies similar to those described for seizure-activated EGFP(+) microglia in the hippocampus of cfms (CSF-1R) EGFP mice. Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population. The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed to identify dendritic cells in the periphery (Lindquist et al. [2004] Nat. Immunol. 5:1243-1250). In this study, we used this mouse to characterize dendritic cells within the CNS. Our anatomic results showed discrete populations of EYFP(+) brain dendritic cells (EYFP(+) bDC) that colocalized with a small fraction of microglia immunoreactive for Mac-1, Iba-1, CD45, and F4/80 but not for NeuN, Dcx, NG2 proteoglycan, or GFAP. EYFP(+) bDC, isolated by fluorescent activated cell sorting (FACS), expressed mRNA for the Itgax (CD11c) gene, whereas FACS anlaysis of EYFP(+) bDC cultures revealed the presence of CD11c protein. Light microscopy studies revealed that EYFP(+) bDC were present in the embryonic CNS when the blood-brain barrier is formed and postnatally when brain cells are amenable to culturing. In adult male mice, EYFP(+) bDC distribution was prominent within regions of the CNS that 1) are subject to structural plasticity and neurogenesis, 2) receive sensory and humoral input from the external environment, and 3) lack a blood-brain barrier. Ultrastructural analysis of EYFP(+) bDC in adult neurogenic niches showed their proximity to developing neurons and a morphology characteristic of immune/microglia cells. Kainic acid-induced seizures revealed that EYFP(+) bDC responded to damage of the hippocampus and displayed morphologies similar to those described for seizure-activated EGFP(+) microglia in the hippocampus of cfms (CSF-1R) EGFP mice. Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population.The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed to identify dendritic cells in the periphery (Lindquist et al. [2004] Nat. Immunol. 5:1243-1250). In this study, we used this mouse to characterize dendritic cells within the CNS. Our anatomic results showed discrete populations of EYFP(+) brain dendritic cells (EYFP(+) bDC) that colocalized with a small fraction of microglia immunoreactive for Mac-1, Iba-1, CD45, and F4/80 but not for NeuN, Dcx, NG2 proteoglycan, or GFAP. EYFP(+) bDC, isolated by fluorescent activated cell sorting (FACS), expressed mRNA for the Itgax (CD11c) gene, whereas FACS anlaysis of EYFP(+) bDC cultures revealed the presence of CD11c protein. Light microscopy studies revealed that EYFP(+) bDC were present in the embryonic CNS when the blood-brain barrier is formed and postnatally when brain cells are amenable to culturing. In adult male mice, EYFP(+) bDC distribution was prominent within regions of the CNS that 1) are subject to structural plasticity and neurogenesis, 2) receive sensory and humoral input from the external environment, and 3) lack a blood-brain barrier. Ultrastructural analysis of EYFP(+) bDC in adult neurogenic niches showed their proximity to developing neurons and a morphology characteristic of immune/microglia cells. Kainic acid-induced seizures revealed that EYFP(+) bDC responded to damage of the hippocampus and displayed morphologies similar to those described for seizure-activated EGFP(+) microglia in the hippocampus of cfms (CSF-1R) EGFP mice. Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population. |
| Author | Nussenzweig, Michel C. Bulloch, Karen Milner, Teresa A. Gottfried-Blackmore, Andres Lindquist, Randall McEwen, Bruce S. Liu, Kang Steinman, Ralph M. Gal-Toth, Judit Waters, Elizabeth M. Miller, Melinda M. Kaunzner, Ulrike W. |
| Author_xml | – sequence: 1 givenname: Karen surname: Bulloch fullname: Bulloch, Karen email: bulloch@rockefeller.edu organization: Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10065 – sequence: 2 givenname: Melinda M. surname: Miller fullname: Miller, Melinda M. organization: Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, New York 10021 – sequence: 3 givenname: Judit surname: Gal-Toth fullname: Gal-Toth, Judit organization: Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, New York 10021 – sequence: 4 givenname: Teresa A. surname: Milner fullname: Milner, Teresa A. organization: Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, New York 10021 – sequence: 5 givenname: Andres surname: Gottfried-Blackmore fullname: Gottfried-Blackmore, Andres organization: Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, New York 10021 – sequence: 6 givenname: Elizabeth M. surname: Waters fullname: Waters, Elizabeth M. organization: Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, New York 10021 – sequence: 7 givenname: Ulrike W. surname: Kaunzner fullname: Kaunzner, Ulrike W. organization: Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, New York 10021 – sequence: 8 givenname: Kang surname: Liu fullname: Liu, Kang organization: Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10065 – sequence: 9 givenname: Randall surname: Lindquist fullname: Lindquist, Randall organization: Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065 – sequence: 10 givenname: Michel C. surname: Nussenzweig fullname: Nussenzweig, Michel C. organization: Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065 – sequence: 11 givenname: Ralph M. surname: Steinman fullname: Steinman, Ralph M. organization: Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10065 – sequence: 12 givenname: Bruce S. surname: McEwen fullname: McEwen, Bruce S. organization: Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, New York 10021 |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18386786$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2008 Wiley‐Liss, Inc. |
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| Snippet | The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed to identify dendritic cells in the periphery (Lindquist et al. [2004]... The CD11c enhanced yellow fluorescent protein (EYFP) transgenic mouse was constructed to identify dendritic cells in the periphery (Lindquist et al. [ 2004 ]... |
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| SubjectTerms | Age Factors Animals Animals, Newborn Bacterial Proteins - analysis Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Brain - cytology Brain - embryology Brain - physiology Brain Injuries - genetics Brain Injuries - metabolism Brain Injuries - pathology CD11c Antigen - analysis CD11c Antigen - biosynthesis CD11c Antigen - genetics Cells, Cultured central nervous system Dendritic Cells - cytology Dendritic Cells - physiology Female immune system Luminescent Proteins - analysis Luminescent Proteins - biosynthesis Luminescent Proteins - genetics Male Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic neurogenesis Pregnancy steady state Transgenes - physiology transgenic mouse |
| Title | CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain |
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