P253R fibroblast growth factor receptor-2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation

Unregulated fibroblast growth factor 2 (FGF2) signaling caused by mutations in the fibroblast growth factor receptor (FGFR2) leads to human craniosynostosis such as the Apert syndrome. In an in vitro control model of calvarial osteoblasts from Apert patients carrying the FGFR2 P253R mutation, we stu...

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Published inJournal of cellular physiology Vol. 202; no. 2; pp. 524 - 535
Main Authors Baroni, Tiziano, Carinci, Paolo, Lilli, Cinzia, Bellucci, Catia, Aisa, Maria Cristina, Scapoli, Luca, Volinia, Stefano, Carinci, Francesco, Pezzetti, Furio, Calvitti, Mario, Farina, Antonio, Conte, Carmela, Bodo, Maria
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2005
Subjects
Acrocephalosyndactylia - genetics
Acrocephalosyndactylia - pathology
Adolescent
Arginine
Cell Differentiation
Cells, Cultured
Core Binding Factor Alpha 1 Subunit
Genetic Variation
Humans
Mutation
Neoplasm Proteins - genetics
Osteoblasts - pathology
Parietal Bone
Proline
Receptor Protein-Tyrosine Kinases - genetics
Receptor, Fibroblast Growth Factor, Type 2
Receptors, Fibroblast Growth Factor - genetics
RNA, Messenger - genetics
Transcription Factors - genetics
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Abstract Unregulated fibroblast growth factor 2 (FGF2) signaling caused by mutations in the fibroblast growth factor receptor (FGFR2) leads to human craniosynostosis such as the Apert syndrome. In an in vitro control model of calvarial osteoblasts from Apert patients carrying the FGFR2 P253R mutation, we studied the changes in cellular phenotype and evaluated the effects of FGF2. Compared with wild‐type controls, osteocalcin mRNA was down‐regulated in Apert osteoblasts, Runt‐related transcription factor‐2 (RUNX2) mRNA was differentially spliced, and FGF2 secretion was greater. Total protein synthesis, fibronectin and type I collagen secretion were up‐regulated, while protease and glycosidase activities and matrix metalloproteinase‐13 (MMP‐13) transcription were decreased, suggesting an altered ECM turnover. Adding FGF2 increased protease and glycosidase activities and down‐regulated fibronectin and type I collagen secretion in Apert osteoblasts. High affinity FGF2 receptors were up‐regulated in Apert osteoblasts and analysis of signal transduction showed elevated levels of Grb2 tyrosine phosphorylation and the Grb2‐p85 beta association, which FGF2 stimulation strongly reduced. All together these findings suggest increased constitutive receptor activity in Apert mutant osteoblasts and an autocrine loop involving the FGF2 pathway in modulation of Apert osteoblast behavior. © 2004 Wiley‐Liss, Inc.
AbstractList Unregulated fibroblast growth factor 2 (FGF2) signaling caused by mutations in the fibroblast growth factor receptor (FGFR2) leads to human craniosynostosis such as the Apert syndrome. In an in vitro control model of calvarial osteoblasts from Apert patients carrying the FGFR2 P253R mutation, we studied the changes in cellular phenotype and evaluated the effects of FGF2. Compared with wild‐type controls, osteocalcin mRNA was down‐regulated in Apert osteoblasts, Runt‐related transcription factor‐2 (RUNX2) mRNA was differentially spliced, and FGF2 secretion was greater. Total protein synthesis, fibronectin and type I collagen secretion were up‐regulated, while protease and glycosidase activities and matrix metalloproteinase‐13 (MMP‐13) transcription were decreased, suggesting an altered ECM turnover. Adding FGF2 increased protease and glycosidase activities and down‐regulated fibronectin and type I collagen secretion in Apert osteoblasts. High affinity FGF2 receptors were up‐regulated in Apert osteoblasts and analysis of signal transduction showed elevated levels of Grb2 tyrosine phosphorylation and the Grb2‐p85 beta association, which FGF2 stimulation strongly reduced. All together these findings suggest increased constitutive receptor activity in Apert mutant osteoblasts and an autocrine loop involving the FGF2 pathway in modulation of Apert osteoblast behavior. © 2004 Wiley‐Liss, Inc.
Unregulated fibroblast growth factor 2 (FGF2) signaling caused by mutations in the fibroblast growth factor receptor (FGFR2) leads to human craniosynostosis such as the Apert syndrome. In an in vitro control model of calvarial osteoblasts from Apert patients carrying the FGFR2 P253R mutation, we studied the changes in cellular phenotype and evaluated the effects of FGF2. Compared with wild-type controls, osteocalcin mRNA was down-regulated in Apert osteoblasts, Runt-related transcription factor-2 (RUNX2) mRNA was differentially spliced, and FGF2 secretion was greater. Total protein synthesis, fibronectin and type I collagen secretion were up-regulated, while protease and glycosidase activities and matrix metalloproteinase-13 (MMP-13) transcription were decreased, suggesting an altered ECM turnover. Adding FGF2 increased protease and glycosidase activities and down-regulated fibronectin and type I collagen secretion in Apert osteoblasts. High affinity FGF2 receptors were up-regulated in Apert osteoblasts and analysis of signal transduction showed elevated levels of Grb2 tyrosine phosphorylation and the Grb2-p85 beta association, which FGF2 stimulation strongly reduced. All together these findings suggest increased constitutive receptor activity in Apert mutant osteoblasts and an autocrine loop involving the FGF2 pathway in modulation of Apert osteoblast behavior.
Author Calvitti, Mario
Aisa, Maria Cristina
Scapoli, Luca
Bodo, Maria
Conte, Carmela
Carinci, Francesco
Carinci, Paolo
Farina, Antonio
Baroni, Tiziano
Pezzetti, Furio
Bellucci, Catia
Volinia, Stefano
Lilli, Cinzia
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  surname: Bodo
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  email: bodo@unipg.it
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Snippet Unregulated fibroblast growth factor 2 (FGF2) signaling caused by mutations in the fibroblast growth factor receptor (FGFR2) leads to human craniosynostosis...
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SubjectTerms Acrocephalosyndactylia - genetics
Acrocephalosyndactylia - pathology
Adolescent
Arginine
Cell Differentiation
Cells, Cultured
Core Binding Factor Alpha 1 Subunit
Genetic Variation
Humans
Mutation
Neoplasm Proteins - genetics
Osteoblasts - pathology
Parietal Bone
Proline
Receptor Protein-Tyrosine Kinases - genetics
Receptor, Fibroblast Growth Factor, Type 2
Receptors, Fibroblast Growth Factor - genetics
RNA, Messenger - genetics
Transcription Factors - genetics
Title P253R fibroblast growth factor receptor-2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation
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https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjcp.20148
https://www.ncbi.nlm.nih.gov/pubmed/15389579
https://search.proquest.com/docview/67308001
Volume 202
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