Therapeutic plasmapheresis as a bridge to liver transplantation in fulminant Wilson disease

• Published in: Journal of clinical apheresis Vol. 22; no. 1; pp. 10 - 14
• Main Authors: Jhang, Jeffrey S., Schilsky, Michael L., Lefkowitch, Jay H., Schwartz, Joseph
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2007
• Subjects: Adult; copper; Copper - blood; Copper - urine; Female; hemolysis; hepatolenticular; Hepatolenticular Degeneration - therapy; Humans; liver failure; Liver Function Tests; Liver Transplantation - methods; Plasmapheresis - methods; Treatment Outcome

Wilson disease is an autosomal recessive disorder of copper metabolism that leads to the accumulation of copper mainly in the liver, cornea, brain, and kidney. Rarely, Wilson disease can present as fulminant hepatic failure with direct antiglobulin test–negative hemolytic anemia and renal failure. I...