Electroencephalographic Seizures After Neonatal Cardiac Surgery with High-Flow Cardiopulmonary Bypass

• Published in: Anesthesia and analgesia Vol. 110; no. 6; pp. 1680 - 1685
• Main Authors: Andropoulos, Dean B., Mizrahi, Eli M., Hrachovy, Richard A., Stayer, Stephen A., Stark, Ann R., Heinle, Jeffrey S., McKenzie, Emmitt D., Dickerson, Heather A., Meador, Marcie R., Fraser, Charles D.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD International Anesthesia Research Society 01.06.2010; Lippincott Williams & Wilkins
• Subjects: Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics - therapeutic use; Biological and medical sciences; Brain Chemistry - physiology; Cardiac Surgical Procedures - adverse effects; Cardiopulmonary Bypass - adverse effects; Cerebrovascular Circulation - physiology; Electroencephalography; Female; Heart Defects, Congenital - surgery; Heart Ventricles - abnormalities; Humans; Hypnotics and Sedatives - therapeutic use; Infant, Newborn; Magnetic Resonance Imaging; Male; Medical sciences; Oxygen - blood; Oxygen Consumption - physiology; Pain, Postoperative - drug therapy; Perfusion; Postoperative Care; Postoperative Complications - epidemiology; Seizures - epidemiology; Seizures - etiology; Human; Cardiopulmonary bypass; Nervous system diseases; Newborn; Convulsion; Surgery; Epilepsy; Central nervous system disease; Anesthesia; Neurological disorder; Cerebral disorder

Postoperative electroencephalographic (EEG) seizures are reported to occur in 14% to 20% of neonates after cardiac surgery with cardiopulmonary bypass (CPB). EEG seizures are associated with prolonged deep hypothermic circulatory arrest and with adverse long-term neurodevelopmental outcomes. We perf...