Electroencephalographic Seizures After Neonatal Cardiac Surgery with High-Flow Cardiopulmonary Bypass

Postoperative electroencephalographic (EEG) seizures are reported to occur in 14% to 20% of neonates after cardiac surgery with cardiopulmonary bypass (CPB). EEG seizures are associated with prolonged deep hypothermic circulatory arrest and with adverse long-term neurodevelopmental outcomes. We perf...

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Published inAnesthesia and analgesia Vol. 110; no. 6; pp. 1680 - 1685
Main Authors Andropoulos, Dean B., Mizrahi, Eli M., Hrachovy, Richard A., Stayer, Stephen A., Stark, Ann R., Heinle, Jeffrey S., McKenzie, Emmitt D., Dickerson, Heather A., Meador, Marcie R., Fraser, Charles D.
Format Journal Article
LanguageEnglish
Published Hagerstown, MD International Anesthesia Research Society 01.06.2010
Lippincott Williams & Wilkins
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Abstract Postoperative electroencephalographic (EEG) seizures are reported to occur in 14% to 20% of neonates after cardiac surgery with cardiopulmonary bypass (CPB). EEG seizures are associated with prolonged deep hypothermic circulatory arrest and with adverse long-term neurodevelopmental outcomes. We performed video/EEG monitoring before and for 72 hours after neonatal cardiac surgery, using a high-flow CPB protocol and cerebral oxygenation monitoring, to ascertain incidence, severity, and factors associated with EEG seizures. The CPB protocol included 150 mL/kg/min flows, pH stat management, hematocrit >30%, and high-flow antegrade cerebral perfusion. Regional cerebral oxygen saturation (rSo(2)) was monitored, with a treatment protocol for rSo(2) <50%. EEG was assessed for seizures. Sixty-eight patients (36 single ventricle [SV] and 32 2-ventricle [2V]) were monitored for a total of 4824 hours. The total midazolam dose was 2.4 mg/kg (1.5-7.3 mg/kg) (median, 25th-75th percentile) for the SV group and 1.3 mg/kg (1.0-2.7 mg/kg) for the 2V group (P = 0.009). One SV patient experienced 2 brief EEG seizures postoperatively (1.5% incidence; 95% confidence interval: 0.3%-7.9%). The SV patients experienced a significant incidence of cerebral desaturation (rSo(2) <45% for >240 minutes total) perioperatively (18 of 36 SV vs 0 of 32 2V patients, P < 0.001). This difference did not affect electrographic seizure occurrence or other EEG characteristics. EEG seizures are infrequent in neonates undergoing surgery with high-flow CPB. Cerebral desaturation did not affect EEG seizure occurrence; however, benzodiazepines may play a role in suppressing postoperative seizures caused by cerebral hypoxemia in this patient population. Using this anesthetic and surgical protocol, EEG seizures are a poor surrogate marker for acute neurological injury in this population.
AbstractList Postoperative electroencephalographic (EEG) seizures are reported to occur in 14% to 20% of neonates after cardiac surgery with cardiopulmonary bypass (CPB). EEG seizures are associated with prolonged deep hypothermic circulatory arrest and with adverse long-term neurodevelopmental outcomes. We performed video/EEG monitoring before and for 72 hours after neonatal cardiac surgery, using a high-flow CPB protocol and cerebral oxygenation monitoring, to ascertain incidence, severity, and factors associated with EEG seizures. The CPB protocol included 150 mL/kg/min flows, pH stat management, hematocrit >30%, and high-flow antegrade cerebral perfusion. Regional cerebral oxygen saturation (rSo(2)) was monitored, with a treatment protocol for rSo(2) <50%. EEG was assessed for seizures. Sixty-eight patients (36 single ventricle [SV] and 32 2-ventricle [2V]) were monitored for a total of 4824 hours. The total midazolam dose was 2.4 mg/kg (1.5-7.3 mg/kg) (median, 25th-75th percentile) for the SV group and 1.3 mg/kg (1.0-2.7 mg/kg) for the 2V group (P = 0.009). One SV patient experienced 2 brief EEG seizures postoperatively (1.5% incidence; 95% confidence interval: 0.3%-7.9%). The SV patients experienced a significant incidence of cerebral desaturation (rSo(2) <45% for >240 minutes total) perioperatively (18 of 36 SV vs 0 of 32 2V patients, P < 0.001). This difference did not affect electrographic seizure occurrence or other EEG characteristics. EEG seizures are infrequent in neonates undergoing surgery with high-flow CPB. Cerebral desaturation did not affect EEG seizure occurrence; however, benzodiazepines may play a role in suppressing postoperative seizures caused by cerebral hypoxemia in this patient population. Using this anesthetic and surgical protocol, EEG seizures are a poor surrogate marker for acute neurological injury in this population.
BACKGROUNDPostoperative electroencephalographic (EEG) seizures are reported to occur in 14% to 20% of neonates after cardiac surgery with cardiopulmonary bypass (CPB). EEG seizures are associated with prolonged deep hypothermic circulatory arrest and with adverse long-term neurodevelopmental outcomes. We performed video/EEG monitoring before and for 72 hours after neonatal cardiac surgery, using a high-flow CPB protocol and cerebral oxygenation monitoring, to ascertain incidence, severity, and factors associated with EEG seizures.METHODSThe CPB protocol included 150 mL/kg/min flows, pH stat management, hematocrit >30%, and high-flow antegrade cerebral perfusion. Regional cerebral oxygen saturation (rSo(2)) was monitored, with a treatment protocol for rSo(2) <50%. EEG was assessed for seizures.RESULTSSixty-eight patients (36 single ventricle [SV] and 32 2-ventricle [2V]) were monitored for a total of 4824 hours. The total midazolam dose was 2.4 mg/kg (1.5-7.3 mg/kg) (median, 25th-75th percentile) for the SV group and 1.3 mg/kg (1.0-2.7 mg/kg) for the 2V group (P = 0.009). One SV patient experienced 2 brief EEG seizures postoperatively (1.5% incidence; 95% confidence interval: 0.3%-7.9%). The SV patients experienced a significant incidence of cerebral desaturation (rSo(2) <45% for >240 minutes total) perioperatively (18 of 36 SV vs 0 of 32 2V patients, P < 0.001). This difference did not affect electrographic seizure occurrence or other EEG characteristics.CONCLUSIONSEEG seizures are infrequent in neonates undergoing surgery with high-flow CPB. Cerebral desaturation did not affect EEG seizure occurrence; however, benzodiazepines may play a role in suppressing postoperative seizures caused by cerebral hypoxemia in this patient population. Using this anesthetic and surgical protocol, EEG seizures are a poor surrogate marker for acute neurological injury in this population.
Author Stayer, Stephen A.
Fraser, Charles D.
Dickerson, Heather A.
Hrachovy, Richard A.
McKenzie, Emmitt D.
Andropoulos, Dean B.
Heinle, Jeffrey S.
Mizrahi, Eli M.
Stark, Ann R.
Meador, Marcie R.
AuthorAffiliation From the Departments of Anesthesiology, and Pediatrics, Baylor College of Medicine; Division of Pediatric Cardiovascular Anesthesiology, Texas Children's Hospital; Department of Neurology, Baylor College of Medicine; Division of Neurophysiology, Texas Children's Hospital; Michael E DeBakey Veterans Affairs Medical Center; Division of Neonatology, Texas Children's Hospital; Department of Surgery, Baylor College of Medicine; and Congenital Heart Surgery Service, and Division of Pediatric Cardiology, Texas Children's Hospital, Houston, Texas
AuthorAffiliation_xml – name: From the Departments of Anesthesiology, and Pediatrics, Baylor College of Medicine; Division of Pediatric Cardiovascular Anesthesiology, Texas Children's Hospital; Department of Neurology, Baylor College of Medicine; Division of Neurophysiology, Texas Children's Hospital; Michael E DeBakey Veterans Affairs Medical Center; Division of Neonatology, Texas Children's Hospital; Department of Surgery, Baylor College of Medicine; and Congenital Heart Surgery Service, and Division of Pediatric Cardiology, Texas Children's Hospital, Houston, Texas
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  organization: From the Departments of Anesthesiology, and Pediatrics, Baylor College of Medicine; Division of Pediatric Cardiovascular Anesthesiology, Texas Children's Hospital; Department of Neurology, Baylor College of Medicine; Division of Neurophysiology, Texas Children's Hospital; Michael E DeBakey Veterans Affairs Medical Center; Division of Neonatology, Texas Children's Hospital; Department of Surgery, Baylor College of Medicine; and Congenital Heart Surgery Service, and Division of Pediatric Cardiology, Texas Children's Hospital, Houston, Texas
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Keywords Human
Cardiopulmonary bypass
Nervous system diseases
Newborn
Convulsion
Surgery
Epilepsy
Central nervous system disease
Anesthesia
Neurological disorder
Cerebral disorder
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Snippet Postoperative electroencephalographic (EEG) seizures are reported to occur in 14% to 20% of neonates after cardiac surgery with cardiopulmonary bypass (CPB)....
BACKGROUNDPostoperative electroencephalographic (EEG) seizures are reported to occur in 14% to 20% of neonates after cardiac surgery with cardiopulmonary...
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SubjectTerms Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics - therapeutic use
Biological and medical sciences
Brain Chemistry - physiology
Cardiac Surgical Procedures - adverse effects
Cardiopulmonary Bypass - adverse effects
Cerebrovascular Circulation - physiology
Electroencephalography
Female
Heart Defects, Congenital - surgery
Heart Ventricles - abnormalities
Humans
Hypnotics and Sedatives - therapeutic use
Infant, Newborn
Magnetic Resonance Imaging
Male
Medical sciences
Oxygen - blood
Oxygen Consumption - physiology
Pain, Postoperative - drug therapy
Perfusion
Postoperative Care
Postoperative Complications - epidemiology
Seizures - epidemiology
Seizures - etiology
Title Electroencephalographic Seizures After Neonatal Cardiac Surgery with High-Flow Cardiopulmonary Bypass
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https://www.ncbi.nlm.nih.gov/pubmed/20435942
https://search.proquest.com/docview/733119166
Volume 110
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