Polymorphisms of the Tissue Factor Pathway Inhibitor (TFPI) Gene in Patients With Acute Coronary Syndromes and in Healthy Subjects: Impact of the V264M Substitution on Plasma Levels of TFPI

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 19; no. 4; pp. 862 - 869
• Main Authors: Moatti, Didier, Seknadji, Patrick, Galand, Colette, Poirier, Odette, Fumeron, Frederic, Desprez, Sophie, Garbarz, Michel, Dhermy, Didier, Arveiler, Dominique, Evans, Alun, Luc, Gerald, Ruidavets, Jean-Bernard, Ollivier, Veronique, Hakim, Jacques, Aumont, Marie Claude, de Prost, Dominique
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.04.1999; Hagerstown, MD Lippincott
• Subjects: Acute Disease; Adult; Aged; Amino Acid Sequence; Amino Acid Substitution - genetics; Angina, Unstable - epidemiology; Angina, Unstable - genetics; Biological and medical sciences; Cardiology. Vascular system; Case-Control Studies; Coronary Disease - epidemiology; Coronary Disease - genetics; Coronary heart disease; France - epidemiology; Gene Frequency; Genotype; Heart; Humans; Lipoproteins - blood; Lipoproteins - genetics; Male; Medical sciences; Methionine - genetics; Middle Aged; Molecular Sequence Data; Myocardial Infarction - epidemiology; Myocardial Infarction - genetics; Polymorphism, Genetic - genetics; Risk Factors; Syndrome; Valine - genetics; France; Human; Infarct; Acute; Tissue factor; Cardiovascular disease; Metabolic pathway; Coronary heart disease; Myocardial disease; Genetic determinism; Gene; Myocardium; Inhibitor; Polymorphism

Mutations of the gene encoding tissue factor pathway inhibitor (TFPI), an inhibitor of TF-induced activation of the coagulation cascade, were screened for in 130 patients and 142 healthy controls to determine whether these variants contribute to acute coronary syndromes or modify plasma TFPI levels....