Prediabetes Increases the Risk of Frailty in Prefrail Older Adults With Hypertension: Beneficial Effects of Metformin

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 81; no. 7; pp. 1637 - 1643
• Main Authors: Santulli, Gaetano, Visco, Valeria, Varzideh, Fahimeh, Guerra, Germano, Kansakar, Urna, Gasperi, Maurizio, Marro, Anna, Wilson, Scott, Ferrante, Mario Nicola Vittorio, Pansini, Antonella, Pirone, Armando, Di Lorenzo, Francesco, Tartaglia, Domenico, Iaccarino, Guido, Macina, Gaetano, Agyapong, Esther Densu, Forzano, Imma, Jankauskas, Stanislovas S., Komici, Klara, Ciccarelli, Michele, Mone, Pasquale
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.07.2024
• Subjects: Aged; Aged, 80 and over; Blood Glucose - drug effects; Blood Glucose - metabolism; Cognitive Dysfunction - epidemiology; Cognitive Dysfunction - etiology; Cognitive Dysfunction - prevention & control; Female; Frail Elderly; Frailty - epidemiology; Humans; Hypertension - drug therapy; Hypertension - epidemiology; Hypoglycemic Agents - therapeutic use; Insulin Resistance; Male; Metformin - therapeutic use; Prediabetic State - drug therapy; frailty; hyperglycemia; metformin; prediabetic state; aging; cognitive dysfunction; diabetes

BACKGROUND: Prediabetes has garnered increasing attention due to its association with cardiovascular conditions, especially hypertension, which heightens the risk of prefrailty and frailty among older individuals. METHODS: We screened elders with prefrail hypertension from March 2021 to January 2023...