Matricellular protein SPARC is translocated to the nuclei of immortalized murine lens epithelial cells

• Published in: Journal of cellular physiology Vol. 203; no. 1; pp. 286 - 294
• Main Authors: Yan, Qi, Weaver, Matt, Perdue, Nikole, Sage, E. Helene
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2005
• Subjects: Active Transport, Cell Nucleus - physiology; Animals; Cell Line, Transformed; Cell Nucleus - metabolism; Cytoplasm - metabolism; Epidermal Growth Factor - genetics; Epidermal Growth Factor - metabolism; Epithelial Cells - cytology; Epithelial Cells - metabolism; Epithelial Cells - physiology; Homeostasis - physiology; Lens, Crystalline - cytology; Lens, Crystalline - metabolism; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Osteonectin - genetics; Osteonectin - metabolism; Recombinant Proteins - genetics; Recombinant Proteins - pharmacokinetics

The matricellular glycoprotein, secreted protein acidic and rich in cysteine (SPARC), has complex biological activities and is important for lens epithelial cell function and regulation of cataract formation. To understand how SPARC influences lens epithelial cell activity and homeostasis, we have s...