Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium

• Published in: Immunity (Cambridge, Mass.) Vol. 36; no. 3; pp. 427 - 437
• Main Authors: Roberts, Natalie A., White, Andrea J., Jenkinson, William E., Turchinovich, Gleb, Nakamura, Kyoko, Withers, David R., McConnell, Fiona M., Desanti, Guillaume E., Benezech, Cecile, Parnell, Sonia M., Cunningham, Adam F., Paolino, Magdalena, Penninger, Josef M., Simon, Anna Katharina, Nitta, Takeshi, Ohigashi, Izumi, Takahama, Yousuke, Caamano, Jorge H., Hayday, Adrian C., Lane, Peter J.L., Jenkinson, Eric J., Anderson, Graham
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.03.2012; Cell Press
• Subjects: AIRE Protein; Animals; Cell Differentiation - immunology; Cellular Microenvironment; Epithelial Cells - immunology; Female; Fetus - cytology; Fetus - immunology; Male; Medicin och hälsovetenskap; Mice; Mice, Inbred C57BL; Mice, Knockout; Precursor Cells, T-Lymphoid - cytology; Precursor Cells, T-Lymphoid - immunology; Pregnancy; Receptor Activator of Nuclear Factor-kappa B - immunology; Receptors, Antigen, T-Cell, gamma-delta - metabolism; Signal Transduction - immunology; Thymus Gland - cytology; Thymus Gland - immunology; Transcription Factors - deficiency; Transcription Factors - genetics; Transcription Factors - immunology

The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting t...