Gicerin/CD146 is involved in neurite extension of NGF-treated PC12 cells

• Published in: Journal of cellular physiology Vol. 204; no. 2; pp. 632 - 637
• Main Authors: Taira, Eiichi, Kohama, Keiko, Tsukamoto, Yasuhiro, Okumura, Shigeki, Miki, Naomasa
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2005
• Subjects: Animals; Antigens, CD - biosynthesis; Antigens, CD - physiology; CD146 Antigen; Cell Adhesion - physiology; Immunoglobulin Fc Fragments - pharmacology; Nerve Growth Factors - pharmacology; Neural Cell Adhesion Molecules - biosynthesis; Neural Cell Adhesion Molecules - physiology; Neurites - physiology; Neurons - drug effects; Neurons - physiology; PC12 Cells; Rats; Recombinant Fusion Proteins - pharmacology

Gicerin/CD146 is a cell adhesion molecule, which belongs to the immunoglobulin (Ig) superfamily. We have reported that it has a homophilic binding activity, which participates in the neurite extension from embryonic neurons. To elucidate how gicerin is involved in the neurite extension mechanism, we...