Der p2 activates airway smooth muscle cells in a TLR2/MyD88-dependent manner to induce an inflammatory response

• Published in: Journal of cellular physiology Vol. 220; no. 2; pp. 311 - 318
• Main Authors: Chiou, Ya-Ling, Lin, Ching-Yuang
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.08.2009
• Subjects: Animals; Antigens, Dermatophagoides - genetics; Antigens, Dermatophagoides - immunology; Arthropod Proteins; Asthma - immunology; Cells, Cultured; Cytokines - genetics; Cytokines - immunology; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases - genetics; Extracellular Signal-Regulated MAP Kinases - immunology; Humans; Inflammation - metabolism; JNK Mitogen-Activated Protein Kinases - genetics; JNK Mitogen-Activated Protein Kinases - immunology; MAP Kinase Signaling System - immunology; Myeloid Differentiation Factor 88 - genetics; Myeloid Differentiation Factor 88 - immunology; Myocytes, Smooth Muscle - cytology; Myocytes, Smooth Muscle - immunology; NF-kappa B - metabolism; Protein Isoforms - genetics; Protein Isoforms - immunology; Rats; Respiratory System - cytology; Respiratory System - immunology; Toll-Like Receptor 2 - genetics; Toll-Like Receptor 2 - immunology; Toll-Like Receptors - genetics; Toll-Like Receptors - immunology

Der p2 is a major allergen from Dermatophagoides pteronyssinus, the main species of house dust mite and a major inducer of asthma, inducing harmful respiratory inflammatory responses by activating cells in the respiratory tract, leading to an unstable status. We hypothesize that Der p2 may induce lo...