Differential expression of the seven‐pass transmembrane cadherin genes Celsr1‐3 and distribution of the Celsr2 protein during mouse development

Drosophila Flamingo (Fmi) is an evolutionally conserved seven‐pass transmembrane receptor of the cadherin superfamily. Fmi plays multiple roles in patterning neuronal processes and epithelial planar cell polarity. To explore the in vivo roles of Fmi homologs in mammals, we previously cloned one of t...

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Published inDevelopmental dynamics Vol. 223; no. 3; pp. 321 - 332
Main Authors Shima, Yasuyuki, Copeland, Neal G., Gilbert, Debra J., Jenkins, Nancy A., Chisaka, Osamu, Takeichi, Masatoshi, Uemura, Tadashi
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.03.2002
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Abstract Drosophila Flamingo (Fmi) is an evolutionally conserved seven‐pass transmembrane receptor of the cadherin superfamily. Fmi plays multiple roles in patterning neuronal processes and epithelial planar cell polarity. To explore the in vivo roles of Fmi homologs in mammals, we previously cloned one of the mouse homologs, mouse flamingo1/Celsr2. Here, we report the results of our study of its embryonic and postnatal expression patterns together with those of two other paralogs, Celsr1 and Celsr3. Celsr1–3 expression was initiated broadly in the nervous system at early developmental stages, and each paralog showed characteristic expression patterns in the developing CNS. These genes were also expressed in several other organs, including the cochlea, where hair cells develop planar polarity, the kidney, and the whisker. The Celsr2 protein was distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells, and olfactory neurons. Celsr2 is mapped to a distal region of the mouse chromosome 3. We discussed possible functions of seven‐pass transmembrane cadherins in mouse development. © 2002 Wiley‐Liss, Inc.
AbstractList Drosophila Flamingo (Fmi) is an evolutionally conserved seven‐pass transmembrane receptor of the cadherin superfamily. Fmi plays multiple roles in patterning neuronal processes and epithelial planar cell polarity. To explore the in vivo roles of Fmi homologs in mammals, we previously cloned one of the mouse homologs, mouse flamingo1/Celsr2 . Here, we report the results of our study of its embryonic and postnatal expression patterns together with those of two other paralogs, Celsr1 and Celsr3 . Celsr1–3 expression was initiated broadly in the nervous system at early developmental stages, and each paralog showed characteristic expression patterns in the developing CNS. These genes were also expressed in several other organs, including the cochlea, where hair cells develop planar polarity, the kidney, and the whisker. The Celsr2 protein was distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells, and olfactory neurons. Celsr2 is mapped to a distal region of the mouse chromosome 3. We discussed possible functions of seven‐pass transmembrane cadherins in mouse development. © 2002 Wiley‐Liss, Inc.
Drosophila Flamingo (Fmi) is an evolutionally conserved seven-pass transmembrane receptor of the cadherin superfamily. Fmi plays multiple roles in patterning neuronal processes and epithelial planar cell polarity. To explore the in vivo roles of Fmi homologs in mammals, we previously cloned one of the mouse homologs, mouse flamingo1/Celsr2. Here, we report the results of our study of its embryonic and postnatal expression patterns together with those of two other paralogs, Celsr1 and Celsr3. Celsr1-3 expression was initiated broadly in the nervous system at early developmental stages, and each paralog showed characteristic expression patterns in the developing CNS. These genes were also expressed in several other organs, including the cochlea, where hair cells develop planar polarity, the kidney, and the whisker. The Celsr2 protein was distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells, and olfactory neurons. Celsr2 is mapped to a distal region of the mouse chromosome 3. We discussed possible functions of seven-pass transmembrane cadherins in mouse development.
Drosophila Flamingo (Fmi) is an evolutionally conserved seven‐pass transmembrane receptor of the cadherin superfamily. Fmi plays multiple roles in patterning neuronal processes and epithelial planar cell polarity. To explore the in vivo roles of Fmi homologs in mammals, we previously cloned one of the mouse homologs, mouse flamingo1/Celsr2. Here, we report the results of our study of its embryonic and postnatal expression patterns together with those of two other paralogs, Celsr1 and Celsr3. Celsr1–3 expression was initiated broadly in the nervous system at early developmental stages, and each paralog showed characteristic expression patterns in the developing CNS. These genes were also expressed in several other organs, including the cochlea, where hair cells develop planar polarity, the kidney, and the whisker. The Celsr2 protein was distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells, and olfactory neurons. Celsr2 is mapped to a distal region of the mouse chromosome 3. We discussed possible functions of seven‐pass transmembrane cadherins in mouse development. © 2002 Wiley‐Liss, Inc.
Author Gilbert, Debra J.
Takeichi, Masatoshi
Jenkins, Nancy A.
Chisaka, Osamu
Uemura, Tadashi
Copeland, Neal G.
Shima, Yasuyuki
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  email: tuemura@virus.kyoto‐u.ac.jp
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Snippet Drosophila Flamingo (Fmi) is an evolutionally conserved seven‐pass transmembrane receptor of the cadherin superfamily. Fmi plays multiple roles in patterning...
Drosophila Flamingo (Fmi) is an evolutionally conserved seven-pass transmembrane receptor of the cadherin superfamily. Fmi plays multiple roles in patterning...
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SubjectTerms Animals
Blotting, Western
cadherin superfamily
Cadherins - biosynthesis
Cadherins - metabolism
Cell Line
Cells, Cultured
Celsr
Central Nervous System - embryology
Chromosome Mapping
Cloning, Molecular
Crosses, Genetic
Ear, Inner - metabolism
Fetal Proteins
Flamingo
gene mapping
Hippocampus - metabolism
Humans
Immunoblotting
immunohistochemistry
In Situ Hybridization
Mice
Models, Genetic
mouse development
Neurons - metabolism
Purkinje Cells - metabolism
Receptors, Cell Surface - biosynthesis
Receptors, G-Protein-Coupled
RNA - metabolism
RNA, Messenger - metabolism
Time Factors
Tissue Distribution
Transfection
Title Differential expression of the seven‐pass transmembrane cadherin genes Celsr1‐3 and distribution of the Celsr2 protein during mouse development
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fdvdy.10054
https://www.ncbi.nlm.nih.gov/pubmed/11891983
https://search.proquest.com/docview/71514102
Volume 223
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