Day-Night Dip and Early-Morning Surge in Blood Pressure in Hypertension: Prognostic Implications

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 60; no. 1; pp. 34 - 42
• Main Authors: Verdecchia, Paolo, Angeli, Fabio, Mazzotta, Giovanni, Garofoli, Marta, Ramundo, Elisa, Gentile, Giorgio, Ambrosio, Giuseppe, Reboldi, Gianpaolo
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.07.2012; Lippincott Williams & Wilkins
• Subjects: Adult; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - physiology; Blood Pressure Monitoring, Ambulatory - methods; Blood Pressure Monitoring, Ambulatory - statistics & numerical data; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Female; Follow-Up Studies; Humans; Hypertension - diagnosis; Hypertension - physiopathology; Kaplan-Meier Estimate; Male; Medical sciences; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; Hypertension; nondippers; Prognosis; Night; Morning; Cardiovascular disease; Sleep; Arterial pressure; Blood pressure; ambulatory blood pressure; Ambulatory; dippers; morning blood pressure surge; Monitoring; blood pressure monitoring

We investigated the relationship between the day-night blood pressure (BP) dip and the early morning BP surge in an cohort of 3012 initially untreated subjects with essential hypertension. The day-night reduction in systolic BP showed a direct association with the sleep trough (r=0.564; P<0.0001)...