Regulation of PAI-1 gene expression during adipogenesis

• Published in: Journal of cellular biochemistry Vol. 101; no. 2; pp. 369 - 380
• Main Authors: Venugopal, Joshi, Hanashiro, Kazuhiko, Nagamine, Yoshikuni
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.05.2007
• Subjects: 3T3 Cells; adipocyte; Adipogenesis - physiology; Animals; cardiovascular; E2F Transcription Factors - genetics; E2F Transcription Factors - metabolism; Gene Expression Regulation; Humans; insulin; Mice; Peptides - genetics; Peptides - metabolism; Plasminogen Activator Inhibitor 1 - genetics; Plasminogen Activator Inhibitor 1 - metabolism; Retinoblastoma Protein - genetics; Retinoblastoma Protein - metabolism; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Serine Proteinase Inhibitors - genetics; Serine Proteinase Inhibitors - metabolism; Transcription, Genetic

Obesity is characterized by elevated levels of circulating plasminogen activator inhibitor‐1 (PAI‐1), which contribute towards the development of secondary disorders such as type 2 diabetes mellitus and cardiovascular complications. This increase in plasma PAI‐1 levels is attributed to an increase i...