Evidence of SARS-CoV-2 bacteriophage potential in human gut microbiota [version 2; peer review: 1 approved, 1 approved with reservations]

• Published in: F1000 research Vol. 11; p. 292
• Main Authors: Petrillo, Mauro, Querci, Maddalena, Brogna, Carlo, Ponti, Jessica, Cristoni, Simone, Markov, Peter V, Valsesia, Andrea, Leoni, Gabriele, Benedetti, Alessandro, Wiss, Thierry, Van den Eede, Guy
• Format: Journal Article
• Language: English
• Published: England Faculty of 1000 Ltd 2022; F1000 Research Limited; F1000 Research Ltd
• Subjects: Antibiotics; Antibodies; Bacteria; Bacteriophages - isolation & purification; Bacteriophages - physiology; Coronaviruses; COVID-19; COVID-19 - virology; Disease transmission; eng; Experiments; Feces; Feces - microbiology; Gastrointestinal Microbiome; Genomes; Gut microbiota; Humans; Inoculation; Intestinal microflora; Laboratories; Mass spectrometry; Microbiota; Microscopy; Nucleocapsids; Peptides; Phages; Plaques; Protein biosynthesis; Proteins; Reference materials; Replication; SARS-CoV-2; SARS-CoV-2 - genetics; SARS-CoV-2 - isolation & purification; SARS-CoV-2 - physiology; Scientific imaging; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - biosynthesis; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - metabolism; Spike protein; United States > US; Italy; COVID-19; SARS-CoV-2; gut microbiota

Background In previous studies we have shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in vitro in bacterial growth medium, that the viral replication follows bacterial growth, and it is influenced by the administration of specific antibiotics. These observations a...