The kinetics of the alkaline degradation of daptomycin

• Published in: Journal of pharmaceutical sciences Vol. 90; no. 8; pp. 1066 - 1075
• Main Authors: Muangsiri, Walaisiri, Kirsch, Lee E.
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.08.2001; John Wiley & Sons, Inc; Wiley; American Pharmaceutical Association
• Subjects: Alkalies - chemistry; Anti-Bacterial Agents - chemistry; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Buffers; Chromatography, High Pressure Liquid; daptomycin; Daptomycin - chemistry; drug stability; ester hydrolysis; General pharmacology; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; lipopeptide antibiotic; Medical sciences; peptide degradation pathway; pH-rate profile; Pharmacology. Drug treatments; Physicochemical properties. Structure-activity relationships; Salts; Solutions; Surface Tension; Temperature; Water; daptomycin; ester hydrolysis; pH–rate profile; lipopeptide antibiotic; peptide degradation pathway; drug stability; Degradation; Hydrolysis; Ester; Antibiotic; Stability; Salt effect; Daptomycin; Temperature effect; pH; Surface tension; Degradation product; Physicochemical properties

The aqueous degradation of daptomycin, a lipopeptide antibiotic, was investigated as a function of substrate concentration (0.5–10.0 mM), pH (9.0–10.5), buffer concentration (0.06–0.20 M borate, glycinate, or carbonate buffers), temperature (20–50°C), and ionic strength (0.1–0.8). The primary degrad...