The kinetics of the alkaline degradation of daptomycin - Muangsiri, Walaisiri; Kirsch, Lee E. (Journal of pharmaceutical sciences, 2001)
Keywords: Alkalies - chemistry; Anti-Bacterial Agents - chemistry; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Buffers; Chromatography, High Pressure Liquid; daptomycin; Daptomycin - chemistry; drug stability; ester hydrolysis; General pharmacology; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; lipopeptide antibiotic; Medical sciences; peptide degradation pathway; pH-rate profile; Pharmacology. Drug treatments; Physicochemical properties. Structure-activity relationships; Salts; Solutions; Surface Tension; Temperature; Water; daptomycin; ester hydrolysis; pH–rate profile; lipopeptide antibiotic; peptide degradation pathway; drug stability; Degradation; Hydrolysis; Ester; Antibiotic; Stability; Salt effect; Daptomycin; Temperature effect; pH; Surface tension; Degradation product; Physicochemical properties