Olfactory epithelium amyloid-β and paired helical filament-tau pathology in Alzheimer disease

• Published in: Annals of neurology Vol. 67; no. 4; pp. 462 - 469
• Main Authors: Arnold, Steven E., Lee, Edward B., Moberg, Paul J., Stutzbach, Lauren, Kazi, Hala, Han, Li-Ying, Lee, Virginia M. Y., Trojanowski, John Q.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2010; Wiley-Liss
• Subjects: Aged; Aged, 80 and over; alpha-Synuclein - metabolism; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Analysis of Variance; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; DNA-Binding Proteins - metabolism; Female; Humans; Lewy Bodies - metabolism; Lewy Bodies - pathology; Male; Medical sciences; Neurofibrillary Tangles - metabolism; Neurofibrillary Tangles - pathology; Neurology; Olfactory Mucosa - metabolism; Olfactory Mucosa - pathology; Statistics as Topic; tau Proteins - metabolism; Anatomic pathology; Nervous system diseases; Alzheimer disease; Central nervous system disease; Degenerative disease; Amyloid; Olfactory epithelium; Olfactory system; Cerebral disorder

Objective Olfactory dysfunction is common in Alzheimer disease (AD) and other neurodegenerative diseases. Paired helical filament (PHF)‐tau, α‐synuclein, and amyloid‐β lesions occur early and severely in cerebral regions of the olfactory system, and they have also been observed in olfactory epitheli...